Team 1 – METATOX

Our team identifies the mechanisms of action activated by a variety of environmental pollutants, alone or in combination, to understand their influence on the incidence of various pathologies (cancer, liver diseases, neurodegenerative diseases) in order to identify biomarkers. We use and develop cellular, animal and computational models over several main lines of research:

1) Contextual studies to study the sensitizing effects of persistent organic pollutants such as Seveso dioxin on the development of liver fibrosis or demyelination in the central nervous system. We use rodent models and more recently the nematode C. elegans.

2) We are also developing innovative cell models to study, for example, the influence of adipocytes on tumor metabolic phenotype or the effect of inflammatory cells on hepatocyte function.

3) We leverage our data produced in vivo and in vitro to develop computational models of system toxicology. We develop network biology and predictive toxicology models by integrating these data (into European or national projects) providing potential links between the exposure to environmental chemicals and adverse health outcomes.

Keywords: persistent organic pollutants; AhR; metabolic disruption; cancer; chronic liver diseases; computational models

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