Team 6 – GENETIC EPIDEMIOLOGY AND FUNCTIONAL GENOMICS OF MULTIFACTORIAL DISEASES

Genome-wide association studies have successfully identified many risk loci for multifactorial disorders and have raised key questions about (1) commonalities in the etiology and pathophysiology of distinct diseases suggesting the involvement of pleiotropy, (2) the impact of environmental influences (eg. pollutants, microbial infections, diet), environment-genome interactions and epigenetics affecting disease manifestations and (3) the requirement of molecular phenotyping to deepen the patients’ phenotypic information. Our team will focus on the characterisation of environmental factors and epigenetic marks altering genomic regulations and disease manifestations in order to detect specific and shared factors in genetic risk to distinct disorders, with a specific focus on asthma and allergic diseases, obesity and cancer . The project combines genetic epidemiology with physiological and molecular approaches (transcriptomics, epigenomics, metabolomics) in humans and in models of spontaneous or experimentally induced asthma and obesity in rats and mice. The development of statistical tools and mathematical models is a central objective in order to take advantage of the wealth of genomic information that will be generated towards the identification of disease predictive biomarkers and potential therapeutic targets and the definition of fundamental mechanisms accounting for environmental and epigenetic influences modulating genetic risk.

Team leader

  • Dominique GAUGUIER, INSERM researcher, DR-INSERM, Genetic Epidemiology and functional Genomics of Multifactorial Diseases
    dominique.gauguier@-Code to remove to avoid SPAM-upmc.fr

Members

  • Emmanuelle BOUZIGON, INSERM researcher, CR- INSERM, Genetic Epidemiology and functional Genomics of Multifactorial Diseases
    emmanuelle.bouzigon@-Code to remove to avoid SPAM-inserm.fr
  • François BRIAL, Post-doctoral fellow, Genetic Epidemiology and functional Genomics of Multifactorial Diseases
    francois.brial@-Code to remove to avoid SPAM-crc.jussieu.fr
  • Florence DEMENAIS, INSERM researcher, DR- INSERM, Genetic Epidemiology and functional Genomics of Multifactorial Diseases
    florence.demenais@-Code to remove to avoid SPAM-inserm.fr
  • Marie-Hélène DIZIER, INSERM researcher, CR- INSERM, Genetic Epidemiology and functional Genomics of Multifactorial Diseases
    marie-helene.dizier@-Code to remove to avoid SPAM-inserm.fr
  • Patricia JEANNIN, INSERM Engineer, Genetic Epidemiology and functional Genomics of Multifactorial Diseases
    patricia.jeannin@-Code to remove to avoid SPAM-inserm.fr
  • Aurélie LE LAY, INSERM Engineer, Genetic Epidemiology and functional Genomics of Multifactorial Diseases
    aurelie.lelay@-Code to remove to avoid SPAM-crc.jussieu.fr
  • Eve MAUBEC, University Professor, Genetic Epidemiology and functional Genomics of Multifactorial Diseases
    eve.maubec@-Code to remove to avoid SPAM-inserm.fr
  • Hamida MOHAMDI, INSERM Engineer, Genetic Epidemiology and functional Genomics of Multifactorial Diseases
    hamida.mohamdi@-Code to remove to avoid SPAM-inserm.fr
  • Alexandre NUZZO, PhD student, Genetic Epidemiology and functional Genomics of Multifactorial Diseases

Recent Publications

Articles