T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Karine Andréau

lecturer
MetaTox

karine.andreau@-Code to remove to avoid SPAM-u-paris.fr
+33 1 76 53 43 62, room P434

Karine Andréau is an Associate Professor of Cellular Biology and Toxicology (Paris Diderot University) and is interested in the regulation of the cell death apoptosis mediated by environmental pollutants. Her main research activities recently have focused on the mesenchymal epithelial transition. Her teaching activities are complementary with her scientific skills and she is in charge of the first year of the Toxicology Master’s Degree Program.

Karine Andréau obtained her PhD in Cellular and Molecular Biology at University Paris Saclay (1999). During her three post-doctoral fellowships (1999-2004), she worked on the cellular and molecular pathways that are involved in the promotion or inhibition of apoptosis. She joined the Paris Diderot University in 2005 as an Associate professor and focused on the links existing between fine particulate matter (PM) and cell death.

She demonstrated that fine airborne particles prevent apoptosis by activating the aryl hydrocarbon receptor, AhR, (by the PM’s organic components) in combination with the Nrf2 pathway (induced by the PM’s metallic compounds). In 2014, she joined Team 1 of the INSERM Unit 1124 where she has investigated the mesenchymal epithelial transition and fibrosis induced by environmental pollutants (alcohol or dioxin) in human and murine liver and their potential modulations by the antiapoptotic protein DYRK1A.

Recent Publications

Articles

• Impact of Dyrk1A level on alcohol metabolism.
  Renon M, Legrand B, Blanc E, Daubigney F, Bokobza C, Mortreux M, Paul JL, Delabar JM, Rouach H, Andreau K, Janel N : Biochim Biophys Acta, 2016
• The iron component of particulate matter is antiapoptotic: A clue to the development of lung cancer after exposure to atmospheric pollutants?
  Lovera-Leroux M, Crobeddu B, Kassis N, Petit PX, Janel N, Baeza-Squiban A, Andreau K : Biochimie, 2015
• Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity.
  Andreau K, Leroux M, Bouharrour A : Biochem Res Int, 2012
• Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells.
  Hussain S, Thomassen LC, Ferecatu I, Borot MC, Andreau K, Martens JA, Fleury J, Baeza-Squiban A, Marano F, Boland S : Part Fibre Toxicol, 2010
• Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor.
  Ferecatu I, Borot MC, Bossard C, Leroux M, Boggetto N, Marano F, Baeza-Squiban A, Andreau K : Part Fibre Toxicol, 2010
• 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2.
  Ambolet-Camoit A, Bui LC, Pierre S, Chevallier A, Marchand A, Coumoul X, Garlatti M, Andreau K, Barouki R, Aggerbeck M : Toxicol Sci, 2010