T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Martine Aggerbeck

CNRS researcher, CR-CNRS
MetaTox

martine.aggerbeck@-Code to remove to avoid SPAM-u-paris.fr
+33 1 76 53 43 55, room P431

Martine Aggerbeck is a CNRS scientist interested in the effects of persistent organic pollutants, alone or as mixtures (especially dioxin and organochlorine pesticides), on the modifications of gene expression in the liver, the molecular mechanisms involved in these regulations and their metabolic consequences. Both in vitro models, particularly the HepaRG human cell line, and in vivo mouse models, are used for these investigations.

Martine Aggerbeck, a scientist with a permanent CNRS position, investigates the consequences of the exposure to various pollutants (dioxins, pesticides) alone or as mixtures. After binding to transcription factors which are the receptors of these pollutants (such as the AhR (aryl hydrocarbon receptor) for dioxins), these pollutants modify the expression of numerous genes. The effects are studied mainly in murine liver and in human hepatic cellular models, with a focus on the genes that are involved in intermediary metabolism, susceptible to aggravate various pathologies such as type 2 diabetes. The main axes are

1) the role of the pollutant mixtures on carbohydrate metabolism in the HepaRG cell line;

2) the effect of dioxin on alcohol metabolizing enzymes, in collaboration with Dr E. Blanc;

3) the influence of the combination of dioxin with a fat-enriched diet on chronic hepatic diseases in a murine model;

4) the coordination, in the team, of a European project, HEALS, which aims at measuring the European exposome to pollutants and the link of this exposure with several pathologies.

Recent Publications

Articles

• The association between environmental exposures to chlordanes, adiposity and diabetes-related features: a systematic review and meta-analysis.
  Mendes V, Ribeiro C, Delgado I, Peleteiro B, Aggerbeck M, Distel E, Annesi-Maesano I, Sarigiannis D, Ramos E : Sci Rep, 2021
• A dual mixture of persistent organic pollutants modifies carbohydrate metabolism in the human hepatic cell line HepaRG.
  Leblanc AF, Attignon EA, Distel E, Karakitsios SP, Sarigiannis DA, Bortoli S, Barouki R, Coumoul X, Aggerbeck M, Blanc EB : Environ Res, 2019
• Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of α-endosulfan and dioxin in HepaRG human cells.
  Attignon EA, Distel E, Le-Grand B, Leblanc AF, Barouki R, de Oliveira E, Aggerbeck M, Blanc EB : Toxicol In Vitro, 2017
• Novel roles for AhR and ARNT in the regulation of alcohol dehydrogenases in human hepatic cells.
  Attignon EA, Leblanc AF, Le-Grand B, Duval C, Aggerbeck M, Rouach H, Blanc EB : Arch Toxicol, 2016
• Determination of Heavy Metal Concentrations in Normal and Pathological Human Endometrial Biopsies and In Vitro Regulation of Gene Expression by Metals in the Ishikawa and Hec-1b Endometrial Cell Line.
  Guyot E, Solovyova Y, Tomkiewicz C, Leblanc A, Pierre S, El Balkhi S, Le Frère-Belda MA, Lecuru F, Poupon J, Barouki R, Aggerbeck M, Coumoul X : PLoS One, 2015
• Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin) interact in a mixture and downregulate multiple genes involved in human hepatocyte lipid and glucose metabolism.
  Ambolet-Camoit A, Ottolenghi C, Leblanc A, Kim MJ, Letourneur F, Jacques S, Cagnard N, Guguen-Guillouzo C, Barouki R, Aggerbeck M : Biochimie, 2015
• Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin.
  Pierre S, Chevallier A, Teixeira-Clerc F, Ambolet-Camoit A, Bui LC, Bats AS, Fournet JC, Fernandez-Salguero P, Aggerbeck M, Lotersztajn S, Barouki R, Coumoul X : Toxicol Sci, 2013
• A head and neck cancer tumor response-specific gene signature for cisplatin, 5-fluorouracil induction chemotherapy fails with added taxanes.
  Tomkiewicz C, Hans S, Mucchielli MH, Agier N, Delacroix H, Marisa L, Brasnu D, Aggerbeck LP, Badoual C, Barouki R, Aggerbeck M : PLoS One, 2012
• A head and neck cancer tumor response-specific gene signature for Cisplatin, 5-Fluorouracil induction chemotherapy fails with added taxanes.
  Tomkiewicz C, Hans S, Mucchielli MH, Agier N, Delacroix H, Marisa L, Brasnu D, Aggerbeck LP, Badoual C, Barouki R, Aggerbeck M : PLoS One, 2012
• The aryl hydrocarbon receptor system.
  Barouki R, Aggerbeck M, Aggerbeck L, Coumoul X : Drug Metabol Drug Interact, 2012
• 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2.
  Ambolet-Camoit A, Bui LC, Pierre S, Chevallier A, Marchand A, Coumoul X, Garlatti M, Andreau K, Barouki R, Aggerbeck M : Toxicol Sci, 2010
• Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation.
  Pierre S, Bats AS, Chevallier A, Bui LC, Ambolet-Camoit A, Garlatti M, Aggerbeck M, Barouki R, Coumoul X : Biochem Pharmacol, 2010
• PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes.
  Thulin P, Rafter I, Stockling K, Tomkiewicz C, Norjavaara E, Aggerbeck M, Hellmold H, Ehrenborg E, Andersson U, Cotgreave I, Glinghammar B : Toxicol Appl Pharmacol, 2008
• Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione.
  Tordjman J, Leroyer S, Chauvet G, Quette J, Chauvet C, Tomkiewicz C, Chapron C, Barouki R, Forest C, Aggerbeck M, Antoine B : J Biol Chem, 2007
• Cholesteryl ester hydroperoxides increase macrophage CD36 gene expression via PPARalpha.
  Jedidi I, Couturier M, Thérond P, Gardès-Albert M, Legrand A, Barouki R, Bonnefont-Rousselot D, Aggerbeck M : Biochem Biophys Res Commun, 2006
• Opposite regulation of the rat and human cytosolic aspartate aminotransferase genes by fibrates.
  Tomkiewicz C, Muzeau F, Edgar AD, Barouki R, Aggerbeck M : Biochem Pharmacol, 2004
• Determination of interleukin-4-responsive region in the human cytochrome P450 2E1 gene promoter.
  Abdel-Razzak Z, Garlatti M, Aggerbeck M, Barouki R : Biochem Pharmacol, 2004