T3S-1124 - UMR-S 1124
Université Paris Descartes
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Sylvie BORTOLI

University researcher, IR
MetaTox

sylvie.bortoli@-Code to remove to avoid SPAM-parisdescartes.fr
+33 1 76 53 43 75, room P461

Sylvie Bortoli is Research Engineer (IR1) at the University Paris Descartes and she is a member of INSERM UMRS-1124 since January 2005. She investigates the impact of environmental pollutants on the initiation and the progression of the tumoral phenotype. She is also involved in the teaching of the cancer cell metabolism in the Master degree program “Toxicology, Environment, Health” at the University Paris Descartes, and in the Master Degree program “Nutrition, Metabolism and Signaling” at the University Paris Diderot.

Sylvie has obtained her PhD in Biology at the University Paris Sud in 1997, with a work on the regulation of the insulin receptor expression. During her postdoctoral fellowship, she was involved in the gene expression profiling of stem cell populations from various tissues using transcriptomic approaches. She also participated in the molecular and functional characterization of muscle stem cells.

She worked for 10 years in the field of adipose tissue physiopathology, metabolic disorders and cancer cell metabolism. She has joined the team in 2010 and has developed several projects related to the effects of environmental pollutants on the energy metabolism, in link with the tumor phenotype progression.

Recent Publications

Articles

• The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.
  Saunier E, Benelli C, Bortoli S : Int J Cancer, 2015
• Down-regulation of the phosphoenolpyruvate carboxykinase gene in human colon tumors and induction by omega-3 fatty acids.
  Blouin JM, Bortoli S, Nacfer M, Collinet M, Penot G, Laurent-Puig P, Forest C : Biochimie, 2010
• Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.
  Blouin JM, Penot G, Collinet M, Nacfer M, Forest C, Laurent-Puig P, Coumoul X, Barouki R, Benelli C, Bortoli S : Int J Cancer, 2010
• Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue.
  Cadoudal T, Distel E, Durant S, Fouque F, Blouin JM, Collinet M, Bortoli S, Forest C, Benelli C : Diabetes, 2008