T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Pierre Nioche

Associate professor, MCU Paris Descartes
Stem cells, Signaling and prions

pierre.nioche@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 22 20, room R 280

Pierre Nioche is a Principal Investigator in a structural biology group in INSERM UMR-S1124. His passion is to discover the inner working mechanism of proteins at the atomic level by studying their dynamics and reactivity. He is also a Professor at the University Paris Descartes where he delivers lectures on mathematics, physics, biochemistry and structural biology to undergraduate students.

Pierre Nioche first studied mathematics and physics at the University. Then he moved to biophysics, structural biology and biochemistry. He obtained a Master’s degree in Biophysics and a Ph.D. in Structural Biology from the University Pierre and Marie Curie (University of Paris 6). He then worked for several years in the laboratory of Dr. C. S. Raman at the University of Texas-Houston Medical School (USA). He worked mainly on the soluble Guanylate Cyclase (sGC), the NO receptor in humans, and on cytochrome P450s which gave rise to two major publications in 2004 and 2008. With the help of Avenir and INSERM/University Paris Descartes Chair programs he returned to France to create his own research group.

His goal is now to understand the molecular mechanisms of several proteins such as xenobiotic and NO receptors, cytochrome P450s and purine metabolism enzymes.

Recent Publications

Articles

• T cell apoptosis characterizes severe Covid-19 disease.
  André S, Picard M, Cezar R, Roux-Dalvai F, Alleaume-Butaux A, Soundaramourty C, Cruz AS, Mendes-Frias A, Gotti C, Leclercq M, Nicolas A, Tauzin A, Carvalho A, Capela C, Pedrosa J, Castro AG, Kundura L, Loubet P, Sotto A, Muller L, Lefrant JY, Roger C, Claret PG, Duvnjak S, Tran TA, Racine G, Zghidi-Abouzid O, Nioche P, Silvestre R, Droit A, Mammano F, Corbeau P, Estaquier J : Cell Death Differ, 2022
• Picosecond to second dynamics reveals a structural transition in Clostridium botulinum NO-sensor triggered by the activator BAY-41-2272.
  Yoo BK, Lamarre I, Rappaport F, Nioche P, Raman CS, Martin JL, Negrerie M : ACS Chem Biol, 2012
• Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes.
  Lee DS, Nioche P, Hamberg M, Raman CS : Nature, 2008
• Dynamics of NO rebinding to the heme domain of NO synthase-like proteins from bacterial pathogens.
  Gautier C, Mikula I, Nioche P, Martasek P, Raman CS, Slama-Schwok A : Nitric Oxide, 2006
• Analogies and surprising differences between recombinant nitric oxide synthase-like proteins from Staphylococcus aureus and Bacillus anthracis in their interactions with l-arginine analogs and iron ligands.
  Salard I, Mercey E, Rekka E, Boucher JL, Nioche P, Mikula I, Martasek P, Raman CS, Mansuy D : J Inorg Biochem, 2006
• Femtomolar sensitivity of a NO sensor from Clostridium botulinum.
  Nioche P, Berka V, Vipond J, Minton N, Tsai AL, Raman CS : Science, 2004
• Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
  Nioche P, Liu WQ, Broutin I, Charbonnier Franck, Latreille MT, Vidal M, Roques B, Garbay C, Ducruix A : J Mol Biol, 2002