T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06
Fax : +33 (0) 1 42 86 38 68
Pr. Odile Kellermann
University Professor
Stem cells, Signaling and prions
odile.kellermann@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 20 65, room R287
Odile Kellermann was a student at the Ecole Normale Supérieure (ENS – Ulm). She obtained a teaching degree (« Agrégation ») of Biochemistry-Physiology and defended a Ph.D. in Biochemistry (University Paris VII). She is Professor (PREX) at the University Paris Sud Orsay – ENS-Ulm and co-head of the team « Stem Cells, Signaling and Prions » at the University Paris Descartes.
Since the seventies, Odile Kellermann has been involved in stem cell research. As a student in François Jacob’s laboratory at the Pasteur Institute, she developed a strategy of immortalization of precursors of mesodermal, neuroectodermal and endodermal lineages. Since 1987, the central theme of research of the team has dealt with the signaling pathways that sustain the homeostasis of stem cells, the coordinated implementation of specialized phenotypic functions and the maintenance of a differentiated state.
Awards: Nominated at the “Institut Universitaire de France”, as Junior Member (1991). Chevalier dans l’Ordre de la Légion d’Honneur (1997). Laureate of the Sciences Academia, prize “Dr. et Mme Henri Labbé” (2002); “Officier des Palmes Académiques” (2002).
Recent Publications
Articles
- Serotonin in stem cell based-dental repair and bone formation: A review.
Baudry A, Schneider B, Launay JM, Kellermann O : Biochimie, 2019 - Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.
Baudry A, Pietri M, Launay JM, Kellermann O, Schneider B : Front Neurosci, 2019 - Production of seedable Amyloid-β peptides in model of prion diseases upon PrP-induced PDK1 overactivation.
Ezpeleta J, Baudouin V, Arellano-Anaya ZE, Boudet-Devaud F, Pietri M, Baudry A, Haeberlé AM, Bailly Y, Kellermann O, Launay JM, Schneider B : Nat Commun, 2019 - Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase.
Ezpeleta J, Boudet-Devaud F, Pietri M, Baudry A, Baudouin V, Alleaume-Butaux A, Dagoneau N, Kellermann O, Launay JM, Schneider B : Sci Rep, 2017 - Essential Roles of Dopamine and Serotonin in Tooth Repair: Functional Interplay Between Odontogenic Stem Cells and Platelets.
Baudry A, Alleaume-Butaux A, Dimitrova-Nakov S, Goldberg M, Schneider B, Launay JM, Kellermann O : Stem Cells, 2015 - [Activated platelets help to repair teeth through recruitment of pulpal stem cells].
Baudry A, Launay JM, Goldberg M, Schneider B, Kellermann O : Med Sci (Paris), 2015 - Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation.
Alleaume-Butaux A, Nicot S, Pietri M, Baudry A, Dakowski C, Tixador P, Ardila-Osorio H, Haeberlé AM, Bailly Y, Peyrin JM, Launay JM, Kellermann O, Schneider B : PLoS Pathog, 2015 - In vitro bioactivity of Bioroot™ RCS, via A4 mouse pulpal stem cells.
Dimitrova-Nakov S, Uzunoglu E, Ardila-Osorio H, Baudry A, Richard G, Kellermann O, Goldberg M : Dent Mater, 2015 - [From prion diseases to Alzheimer\\’s disease: a common therapeutic target, PDK1].
Pietri M, Alleaume-Butaux A, Launay JM, Kellermann O, Schneider B : Med Sci (Paris), 2014 - Pulp stem cells: implication in reparative dentin formation.
Dimitrova-Nakov S, Baudry A, Harichane Y, Kellermann O, Goldberg M : J Endod, 2014 - Lineage stem cell lines: test tubes to build pathophysiological scenarios and discover therapeutic targets.
Kellermann O : Res Microbiol, 2014 - Dual role of the Trps1 transcription factor in dentin mineralization.
Kuzynski M, Goss M, Bottini M, Yadav MC, Mobley C, Winters T, Poliard A, Kellermann O, Lee B, Millan JL, Napierala D : J Biol Chem, 2014 - Plithotaxis, a collective cell migration, regulates the sliding of proliferating pulp cells located in the apical niche.
Hirata A, Dimitrova-Nakov S, Djole SX, Ardila H, Baudry A, Kellermann O, Simon S, Goldberg M : Connect Tissue Res, 2014 - PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer\\’s diseases.
Pietri M, Dakowski C, Hannaoui S, Alleaume-Butaux A, Hernandez-Rapp J, Ragagnin A, Mouillet-Richard S, Haik S, Bailly Y, Peyrin JM, Launay JM, Kellermann O, Schneider B : Nat Med, 2013 - Deletion of serotonin 2B receptor provokes structural alterations of mouse dental tissues.
Dimitrova-Nakov S, Baudry A, Harichane Y, Collet C, Marchadier A, Kellermann O, Goldberg M : Calcif Tissue Int, 2013 - Understanding the neurospecificity of Prion protein signaling.
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S : Front Biosci (Landmark Ed), 2011 - [miR-16 - a key for adaptive responses of neurons to fluoxetine].
Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O : Med Sci (Paris), 2011 - New views on antidepressant action.
Baudry A, Mouillet-Richard S, Launay JM, Kellermann O : Curr Opin Neurobiol, 2011 - Differential effects of fibromodulin deficiency on mouse mandibular bones and teeth: a micro-CT time course study.
Goldberg M, Marchadier A, Vidal C, Harichane Y, Kamoun-Goldrat A, Kellermann O, Kilts T, Young M : Cells Tissues Organs, 2011 - Neuritogenesis: the prion protein controls β1 integrin signaling activity.
Loubet D, Dakowski C, Pietri M, Pradines E, Bernard S, Callebert J, Ardila-Osorio H, Mouillet-Richard S, Launay JM, Kellermann O, Schneider B : FASEB J, 2011 - MicroRNAs and depression.
Mouillet-Richard S, Baudry A, Launay JM, Kellermann O : Neurobiol Dis, 2011 - Enamel alterations in serotonin 2B receptor knockout mice.
Harichane Y, Dimitrova-Nakov S, Marchadier A, Collet C, Baudry A, Vidal C, Kamoun-Goldrat A, Kellermann O, Goldberg M : Eur J Oral Sci, 2011 - Serotonergic 5-HT(2B) receptor controls tissue-nonspecific alkaline phosphatase activity in osteoblasts via eicosanoids and phosphatidylinositol-specific phospholipase C.
Baudry A, Bitard J, Mouillet-Richard S, Locker M, Poliard A, Launay JM, Kellermann O : J Biol Chem, 2010 - miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants.
Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O : Science, 2010 - Cellular prion protein coupling to TACE-dependent TNF-alpha shedding controls neurotransmitter catabolism in neuronal cells.
Pradines E, Loubet D, Mouillet-Richard S, Manivet P, Launay JM, Kellermann O, Schneider B : J Neurochem, 2009 - The cellular prion protein interacts with the tissue non-specific alkaline phosphatase in membrane microdomains of bioaminergic neuronal cells.
Ermonval M, Baudry A, Baychelier F, Pradines E, Pietri M, Oda K, Schneider B, Mouillet-Richard S, Launay JM, Kellermann O : PLoS One, 2009 - Production of reactive oxygen species is turned on and rapidly shut down in epithelial cells infected with Chlamydia trachomatis.
Boncompain G, Schneider B, Delevoye C, Kellermann O, Dautry-Varsat A, Subtil A : Infect Immun, 2009 - Prions impair bioaminergic functions through serotonin- or catecholamine-derived neurotoxins in neuronal cells.
Mouillet-Richard S, Nishida N, Pradines E, Laude H, Schneider B, Féraudet C, Grassi J, Launay JM, Lehmann S, Kellermann O : J Biol Chem, 2008 - CREB-dependent gene regulation by prion protein: impact on MMP-9 and beta-dystroglycan.
Pradines E, Loubet D, Schneider B, Launay JM, Kellermann O, Mouillet-Richard S : Cell Signal, 2008 - Cellular prion protein signaling in serotonergic neuronal cells.
Mouillet-Richard S, Schneider B, Pradines E, Pietri M, Ermonval M, Grassi J, Richards JG, Mutel V, Launay JM, Kellermann O : Ann N Y Acad Sci, 2007 - Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells.
Pietri M, Caprini A, Mouillet-Richard S, Pradines E, Ermonval M, Grassi J, Kellermann O, Schneider B : J Biol Chem, 2006 - Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells.
Launay JM, Schneider B, Loric S, Da Prada M, Kellermann O : FASEB J, 2006 - Control of bioamine metabolism by 5-HT2B and alpha 1D autoreceptors through reactive oxygen species and tumor necrosis factor-alpha signaling in neuronal cells.
Schneider B, Pietri M, Mouillet-Richard S, Ermonval M, Mutel V, Launay JM, Kellermann O : Ann N Y Acad Sci, 2006 - Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells.
Pietri M, Schneider B, Mouillet-Richard S, Ermonval M, Mutel V, Launay JM, Kellermann O : FASEB J, 2005
Baudry A, Schneider B, Launay JM, Kellermann O : Biochimie, 2019
Baudry A, Pietri M, Launay JM, Kellermann O, Schneider B : Front Neurosci, 2019
Ezpeleta J, Baudouin V, Arellano-Anaya ZE, Boudet-Devaud F, Pietri M, Baudry A, Haeberlé AM, Bailly Y, Kellermann O, Launay JM, Schneider B : Nat Commun, 2019
Ezpeleta J, Boudet-Devaud F, Pietri M, Baudry A, Baudouin V, Alleaume-Butaux A, Dagoneau N, Kellermann O, Launay JM, Schneider B : Sci Rep, 2017
Baudry A, Alleaume-Butaux A, Dimitrova-Nakov S, Goldberg M, Schneider B, Launay JM, Kellermann O : Stem Cells, 2015
Baudry A, Launay JM, Goldberg M, Schneider B, Kellermann O : Med Sci (Paris), 2015
Alleaume-Butaux A, Nicot S, Pietri M, Baudry A, Dakowski C, Tixador P, Ardila-Osorio H, Haeberlé AM, Bailly Y, Peyrin JM, Launay JM, Kellermann O, Schneider B : PLoS Pathog, 2015
Dimitrova-Nakov S, Uzunoglu E, Ardila-Osorio H, Baudry A, Richard G, Kellermann O, Goldberg M : Dent Mater, 2015
Pietri M, Alleaume-Butaux A, Launay JM, Kellermann O, Schneider B : Med Sci (Paris), 2014
Dimitrova-Nakov S, Baudry A, Harichane Y, Kellermann O, Goldberg M : J Endod, 2014
Kellermann O : Res Microbiol, 2014
Kuzynski M, Goss M, Bottini M, Yadav MC, Mobley C, Winters T, Poliard A, Kellermann O, Lee B, Millan JL, Napierala D : J Biol Chem, 2014
Hirata A, Dimitrova-Nakov S, Djole SX, Ardila H, Baudry A, Kellermann O, Simon S, Goldberg M : Connect Tissue Res, 2014
Pietri M, Dakowski C, Hannaoui S, Alleaume-Butaux A, Hernandez-Rapp J, Ragagnin A, Mouillet-Richard S, Haik S, Bailly Y, Peyrin JM, Launay JM, Kellermann O, Schneider B : Nat Med, 2013
Dimitrova-Nakov S, Baudry A, Harichane Y, Collet C, Marchadier A, Kellermann O, Goldberg M : Calcif Tissue Int, 2013
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S : Front Biosci (Landmark Ed), 2011
Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O : Med Sci (Paris), 2011
Baudry A, Mouillet-Richard S, Launay JM, Kellermann O : Curr Opin Neurobiol, 2011
Goldberg M, Marchadier A, Vidal C, Harichane Y, Kamoun-Goldrat A, Kellermann O, Kilts T, Young M : Cells Tissues Organs, 2011
Loubet D, Dakowski C, Pietri M, Pradines E, Bernard S, Callebert J, Ardila-Osorio H, Mouillet-Richard S, Launay JM, Kellermann O, Schneider B : FASEB J, 2011
Mouillet-Richard S, Baudry A, Launay JM, Kellermann O : Neurobiol Dis, 2011
Harichane Y, Dimitrova-Nakov S, Marchadier A, Collet C, Baudry A, Vidal C, Kamoun-Goldrat A, Kellermann O, Goldberg M : Eur J Oral Sci, 2011
Baudry A, Bitard J, Mouillet-Richard S, Locker M, Poliard A, Launay JM, Kellermann O : J Biol Chem, 2010
Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O : Science, 2010
Pradines E, Loubet D, Mouillet-Richard S, Manivet P, Launay JM, Kellermann O, Schneider B : J Neurochem, 2009
Ermonval M, Baudry A, Baychelier F, Pradines E, Pietri M, Oda K, Schneider B, Mouillet-Richard S, Launay JM, Kellermann O : PLoS One, 2009
Boncompain G, Schneider B, Delevoye C, Kellermann O, Dautry-Varsat A, Subtil A : Infect Immun, 2009
Mouillet-Richard S, Nishida N, Pradines E, Laude H, Schneider B, Féraudet C, Grassi J, Launay JM, Lehmann S, Kellermann O : J Biol Chem, 2008
Pradines E, Loubet D, Schneider B, Launay JM, Kellermann O, Mouillet-Richard S : Cell Signal, 2008
Mouillet-Richard S, Schneider B, Pradines E, Pietri M, Ermonval M, Grassi J, Richards JG, Mutel V, Launay JM, Kellermann O : Ann N Y Acad Sci, 2007
Pietri M, Caprini A, Mouillet-Richard S, Pradines E, Ermonval M, Grassi J, Kellermann O, Schneider B : J Biol Chem, 2006
Launay JM, Schneider B, Loric S, Da Prada M, Kellermann O : FASEB J, 2006
Schneider B, Pietri M, Mouillet-Richard S, Ermonval M, Mutel V, Launay JM, Kellermann O : Ann N Y Acad Sci, 2006
Pietri M, Schneider B, Mouillet-Richard S, Ermonval M, Mutel V, Launay JM, Kellermann O : FASEB J, 2005