T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Nicolas Marie

CNRS researcher, CR-CNRS
Pharmacology and Addiction Therapies

nicolas.marie@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 38 89, room H436

Nicolas Marie started his carrier with a Master’s Degree and a Ph.D. (1998-2003, University Paris Descartes), under the supervision of Dr. Stéphane Allouche and Pr. Philippe Jauzac in the biochemistry laboratory of the University Hospital Center of Caen. He worked on the cellular and molecular mechanisms (signaling, desensitization, receptor trafficking) of human (DOR) delta opioid receptor regulation. In 2003, he moved to the laboratory of Dr. Mary McCaffrey (University College Cork, Ireland), as a post-doctoral fellow (for 2 years), to further his theoretical and experimental background on the mechanisms of intracellular trafficking by working on the role of RCP (Rab Coupling Protein) in intracellular vesicle recycling.

After his post-doctoral studies, he joined the team of Dr. Florence Noble (Director of Research, National Center for Scientific Research, CNRS) as a CNRS scientist to work on preclinical research in drug addiction. After few years devoted to the neurobiology of cocaine and opiates, his research interests have shifted to the pharmacotherapy of addiction. Now, his main objective is the prevention of relapse through the development of two main research topics: the first one is the identification and validation of new therapeutic targets for the treatment of addictions and the second topic is the study of the mechanisms of action of existing treatments (mainly the opioid substitution treatments: methadone and buprenorphine). He is also involved in teaching at the master and doctoral level including the co-responsibility of two modules in the new neuroscience master’s  program from Universities Paris Descartes and Paris Diderot (https://master-neuroscience-paris.fr/).

Recent Publications

Articles

• Morphine-Induced Dendritic Spine Remodeling in Rat Nucleus Accumbens Is Corticosterone Dependent.
  Geoffroy H, Canestrelli C, Marie N, Noble F : Int J Neuropsychopharmacol, 2019
• Management of Opioid Addiction With Opioid Substitution Treatments: Beyond Methadone and Buprenorphine.
  Noble F, Marie N : Front Psychiatry, 2018
• Role of pharmacokinetic and pharmacodynamic parameters in neuroadaptations induced by drugs of abuse, with a focus on opioids and psychostimulants.
  Marie N, Canestrelli C, Noble F : Neurosci Biobehav Rev, 2018
• Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat.
  Lebourgeois S, Vilpoux C, Jeanblanc J, Acher F, Marie N, Noble F, Naassila M : Neuropharmacology, 2018
• Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist.
  Hajasova Z, Canestrelli C, Acher F, Noble F, Marie N : Neuropharmacology, 2018
• The opioid receptors as targets for drug abuse medication.
  Noble F, Lenoir M, Marie N : Br J Pharmacol, 2015
• Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment.
  Posa L, Accarie A, Noble F, Marie N : Int J Neuropsychopharmacol, 2015
• Influence of cocaine administration patterns on dopamine receptor regulation.
  Puig S, Marie N, Benturquia N, Noble F : Psychopharmacology (Berl), 2014
• Rewarding or aversive effects of buprenorphine/naloxone combination (Suboxone) depend on conditioning trial duration.
  Canestrelli C, Marie N, Noble F : Int J Neuropsychopharmacol, 2014
• Striatal dopamine D1 and D2 receptors are differentially regulated following buprenorphine or methadone treatment.
  Allouche S, Le Marec T, Coquerel A, Noble F, Marie N : Psychopharmacology (Berl), 2014
• Opioid receptor desensitization: mechanisms and its link to tolerance.
  Allouche S, Noble F, Marie N : Front Pharmacol, 2014
• Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice.
  Mohammed W, Alhaddad H, Marie N, Tardy F, Lamballais F, Risède P, Noble F, Baud FJ, Mégarbane B : Toxicol Lett, 2013
• Transfer of neuroplasticity from nucleus accumbens core to shell is required for cocaine reward.
  Marie N, Canestrelli C, Noble F : PLoS One, 2012
• [Drug dependence: Progress in neurobiology and perspectives in therapeutics].
  Marie N, Noble F : Presse Med, 2012
• Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice.
  Allouche S, Le Marec T, Noble F, Marie N : Prog Neuropsychopharmacol Biol Psychiatry, 2012
• Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization.
  Le Marec T, Marie-Claire C, Noble F, Marie N : Psychopharmacology (Berl), 2011