T3S-1124 - UMR-S 1124
Université Paris Descartes
45 rue des Saints Pères
75270 Paris Cedex 06
Fax : +33 (0) 1 42 86 38 68
Etienne Blanc, Associate Professor of Biochemistry/Molecular Biology at the University Paris Descartes, has been a member of INSERM UMRS-1124 since September 2004. He investigates the effects of alcohol metabolism on the liver and, in particular, the impact of environmental pollutants on alcohol metabolizing enzymes. Part of his teaching is related to his research work and he is responsible for a cursus in the Master’s degree program “Toxicology, Environment, Health”. He also is interested in the development of innovative pedagogical methods at the Villebon-Georges Charpak Institute.
After obtaining, simultaneously, in 1999 a Master’s degree in Biochemistry from the University of Lund (Sweden) and a Master’s degree in Chemistry and Chemical Engineering from the ENCSM (Ecole Nationale Supérieure de Chimie de Montpellier, France), Etienne Blanc pursued a Research Master’s degree in Molecular and Cellular Pharmacology at the University Pierre and Marie Curie (University Paris 6). He then obtained a Ph.D. in Biology, with a specialization in oncology, from the University of Paris-Sud (2004) following research on the identification of genes responsible for the invasion and proliferation of metastatic neuroblastoma cells. In 2005, he was recruited as Associate Professor at the University Paris Descartes and joined the group of Prof. Robert Barouki which is now headed by Prof. Xavier Coumoul.
In association with Prof. Hélène Rouach (University Paris Descartes, his research initially focused on the study of the toxic effects of alcohol in the liver, particularly through the activation of endoplasmic réticulum stress. In collaboration with Dr. Arielle Rosenberg (Cochin Institute), he currently studies the toxicity of alcohol associated with infection by the hepatitis C virus. These studies have evolved into investigations of the impact of some environmental pollutants (dioxins, pesticides) on the regulation of expression of the alcohol metabolizing enzymes and the consequences thereof. Finally, in collaboration with Dr. Martine Aggerbeck, he participates in the team’s research on the study of the mechanisms that participate in the production of liver disease following exposure to these pollutants, alone or in combinations.
- Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of α-endosulfan and dioxin in HepaRG human cells.
Attignon EA, Distel E, Le-Grand B, Leblanc AF, Barouki R, de Oliveira E, Aggerbeck M, Blanc EB : Toxicol In Vitro, 2017
- Impact of Dyrk1A level on alcohol metabolism.
Renon M, Legrand B, Blanc E, Daubigney F, Bokobza C, Mortreux M, Paul JL, Delabar JM, Rouach H, Andreau K, Janel N : Biochim Biophys Acta, 2016
- Novel roles for AhR and ARNT in the regulation of alcohol dehydrogenases in human hepatic cells.
Attignon EA, Leblanc AF, Le-Grand B, Duval C, Aggerbeck M, Rouach H, Blanc EB : Arch Toxicol, 2016
- Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts.
Michot C, Mamoune A, Vamecq J, Viou MT, Hsieh LS, Testet E, Lainé J, Hubert L, Dessein AF, Fontaine M, Ottolenghi C, Fouillen L, Nadra K, Blanc E, Bastin J, Candon S, Pende M, Munnich A, Smahi A, Djouadi F, Carman GM, Romero N, de Keyzer Y, de Lonlay P : Biochim Biophys Acta, 2013
- ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes.
Magne L, Blanc E, Legrand B, Lucas D, Barouki R, Rouach H, Garlatti M : J Hepatol, 2011
- Hypoxia down-regulates CCAAT/enhancer binding protein-alpha expression in breast cancer cells.
Seifeddine R, Dreiem A, Blanc E, Fulchignoni-Lataud MC, Le Frère Belda MA, Lecuru F, Mayi TH, Mazure N, Favaudon V, Massaad C, Barouki R, Massaad-Massade L : Cancer Res, 2008
- Stabilization of IGFBP-1 mRNA by ethanol in hepatoma cells involves the JNK pathway.
Magne L, Blanc E, Marchand A, Fafournoux P, Barouki R, Rouach H, Garlatti M : J Hepatol, 2007