T3S-1124 - UMR-S 1124
Université Paris Descartes
45 rue des Saints Pères
75270 Paris Cedex 06
Fax : +33 (0) 1 42 86 38 68
Dr. Damien LE MENUET
INSERM researcher, CR- INSERM
Myelination and Nervous system pathologies
damien.le-menuet@-Code to remove to avoid SPAM-inserm.fr
+33 1 70 64 99 76, room H330
Damien Le Menuet is INSERM researcher. He develops research projects about the role of steroid and xenobiotic receptors regulating the myelination process.
Mineralocoticoid and Glucococorticoid Receptors (MR and GR respectively) are steroid receptors that both bind glucocorticoid hormones, although acting in different ways. To date, if the role of GR had already been studied in oligodendrocytes (Miyata et al., 2016), and Schwann cells, (Fonte et al., 2005), there is little data on MR action on myelin sheaths (Girard et al., 2010, Groyer et al., 2006). The crucial importance of MR and GR in neuroscience had already been widely demonstrated (Le Menuet and Lombès, 2014) and Damien Le Menuet is committed to better understand the pathophysiological functions of these two receptors in myelination.
Besides, the Xenobiotic Receptor Aryl hydrocarbon Receptor (AhR) was first described as a receptor activated by exogenous molecules identified as environmental pollutants such as dioxins, but it is also able to respond to endogenous ligands such as derivatives of tryptophan. Our group recently identified Ahr as a gene involved in myelination, and in the formation of malignant tumors of the peripheral nerve sheath (Shackleford et al., 2018). In mouse, inactivation of AhR causes motor problems and alteration of the structure of the myelin sheath.
- Implication of Mineralocorticoid and Glucocorticoid Receptors in myelination.
- Role of the AhR Xenobiotic Receptor in myelination
- Role of the AhR Xenobiotic Receptor in Schwann cell tumorigenesis
- UCP1 transrepression in Brown Fat in vivo and mineralocorticoid receptor anti-thermogenic effects.
Kuhn E, Lamribet K, Viengchareun S, Le Menuet D, Fève B, Lombès M : Ann Endocrinol (Paris), 2019
- Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression.
Chen H, Amazit L, Lombès M, Le Menuet D : Neuroscience, 2019
- Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells.
Chen H, Lombès M, Le Menuet D : Mol Brain, 2017
- Paradoxical resistance to high-fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor-overexpressing mice.
Kuhn E, Bourgeois C, Keo V, Viengchareun S, Muscat A, Meduri G, Le Menuet D, Fève B, Lombès M : Am J Physiol Endocrinol Metab, 2014
- The neuronal mineralocorticoid receptor: from cell survival to neurogenesis.
Le Menuet D, Lombès M : Steroids, 2014
- Germ cell nuclear factor regulates gametogenesis in developing gonads.
Sabour D, Xu X, Chung AC, Le Menuet D, Ko K, Tapia N, Araúzo-Bravo MJ, Gentile L, Greber B, Hübner K, Sebastiano V, Wu G, Schöler HR, Cooney AJ : PLoS One, 2014