T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Pr. Charbel Massaad

university Professor
Myelination and Nervous system pathologies

charbel.massaad@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 22 22, room P410

Recent Publications

Articles

• Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway.
  D’Amico D, Biondi O, Januel C, Bezier C, Sapaly D, Clerc Z, El Khoury M, Sundaram VK, Houdebine L, Josse T, Della Gaspera B, Martinat C, Massaad C, Weill L, Charbonnier F : Neuropathol Appl Neurobiol, 2022
• Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice.
  Eid SA, El Massry M, Hichor M, Haddad M, Grenier J, Dia B, Barakat R, Boutary S, Chanal J, Aractingi S, Wiesel P, Szyndralewiez C, Azar ST, Boitard C, Zaatari G, Eid AA, Massaad C : Diabetes, 2020
• Antidepressive effects of targeting ELK-1 signal transduction.
  Apazoglou K, Farley S, Gorgievski V, Belzeaux R, Lopez JP, Grenier J, Ibrahim EC, El Khoury MA, Tse YC, Mongredien R, Barbé A, de Macedo CEA, Jaworski W, Bochereau A, Orrico A, Isingrini E, Guinaudie C, Mikasova L, Louis F, Gautron S, Groc L, Massaad C, Yildirim F, Vialou V, Dumas S, Marti F, Mechawar N, Morice E, Wong TP, Caboche J, Turecki G, Giros B, Tzavara ET : Nat Med, 2018
• Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve.
  Hichor M, Sundaram VK, Eid SA, Abdel-Rassoul R, Petit PX, Borderie D, Bastin J, Eid AA, Manuel M, Grenier J, Massaad C : Sci Rep, 2018
• Mechanical Stretch of High Magnitude Provokes Axonal Injury, Elongation of Paranodal Junctions, and Signaling Alterations in Oligodendrocytes.
  Chierto E, Simon A, Castoldi F, Meffre D, Cristinziano G, Sapone F, Carrete A, Borderie D, Etienne F, Rannou F, Morrison B, Massaad C, Jafarian-Tehrani M : Mol Neurobiol, 2018
• A novel model of trauma-induced cerebellar injury and myelin loss in mouse organotypic cerebellar slice cultures using live imaging.
  Llufriu-Dabén G, Meffre D, Massaad C, Jafarian-Tehrani M : J Neurosci Methods, 2018
• Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis.
  Shackleford G, Sampathkumar NK, Hichor M, Weill L, Meffre D, Juricek L, Laurendeau I, Chevallier A, Ortonne N, Larousserie F, Herbin M, Bièche I, Coumoul X, Beraneck M, Baulieu EE, Charbonnier F, Pasmant E, Massaad C : Proc Natl Acad Sci U S A, 2018
• Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system.
  Llufriu-Dabén G, Carrete A, Chierto E, Mailleux J, Camand E, Simon A, Vanmierlo T, Rose C, Allinquant B, Hendriks JJA, Massaad C, Meffre D, Jafarian-Tehrani M : Neurobiol Dis, 2017
• AhR-deficiency as a cause of demyelinating disease and inflammation.
  Juricek L, Carcaud J, Pelhaitre A, Riday TT, Chevallier A, Lanzini J, Auzeil N, Laprévote O, Dumont F, Jacques S, Letourneur F, Massaad C, Agulhon C, Barouki R, Beraneck M, Coumoul X : Sci Rep, 2017
• Liver X Receptors differentially modulate central myelin gene mRNA levels in a region-, age- and isoform-specific manner.
  Shackleford GG, Grenier J, Abi Habib W, Massaad C, Meffre D : J Steroid Biochem Mol Biol, 2016
• Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum.
  Meffre D, Shackleford G, Hichor M, Gorgievski V, Tzavara ET, Trousson A, Ghoumari AM, Deboux C, Nait Oumesmar B, Liere P, Schumacher M, Baulieu EE, Charbonnier F, Grenier J, Massaad C : Proc Natl Acad Sci U S A, 2015
• IGF-1R Reduction Triggers Neuroprotective Signaling Pathways in Spinal Muscular Atrophy Mice.
  Biondi O, Branchu J, Ben Salah A, Houdebine L, Bertin L, Chali F, Desseille C, Weill L, Sanchez G, Lancelin C, Aïd S, Lopes P, Pariset C, Lécolle S, Côté J, Holzenberger M, Chanoine C, Massaad C, Charbonnier F : J Neurosci, 2015
• Beta-catenin up-regulates the constitutive and virus-induced transcriptional capacity of the interferon-β promoter through T-cell factor binding sites.
  Marcato V, Luron L, Laqueuvre LM, Simon D, Mansuroglu Z, Flamand M, Panthier JJ, Souès S, Massaad C, Bonnefoy E : Mol Cell Biol, 2015
• Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/β-catenin and Akt/CREB pathways.
  Meffre D, Massaad C, Grenier J : Neuroscience, 2014
• Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells.
  Branchu J, Biondi O, Chali F, Collin T, Leroy F, Mamchaoui K, Makoukji J, Pariset C, Lopes P, Massaad C, Chanoine C, Charbonnier F : J Neurosci, 2013
• Wnt and lithium: a common destiny in the therapy of nervous system pathologies?
  Meffre D, Grenier J, Bernard S, Courtin F, Dudev T, Shackleford G, Jafarian-Tehrani M, Massaad C : Cell Mol Life Sci, 2013
• Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes.
  Shackleford G, Makoukji J, Grenier J, Liere P, Meffre D, Massaad C : Biochem Pharmacol, 2013
• The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis.
  Luscan A, Shackleford G, Masliah-Planchon J, Laurendeau I, Ortonne N, Varin J, Lallemand F, Leroy K, Dumaine V, Hivelin M, Borderie D, De Raedt T, Valeyrie-Allanore L, Larousserie F, Terris B, Lantieri L, Vidaud M, Vidaud D, Wolkenstein P, Parfait B, Bièche I, Massaad C, Pasmant E : Clin Cancer Res, 2013
• Lithium enhances remyelination of peripheral nerves.
  Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C : Proc Natl Acad Sci U S A, 2012
• Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis.
  Tawk M, Makoukji J, Belle M, Fonte C, Trousson A, Hawkins T, Li H, Ghandour S, Schumacher M, Massaad C : J Neurosci, 2011
• Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.
  Makoukji J, Shackleford G, Meffre D, Grenier J, Liere P, Lobaccaro JM, Schumacher M, Massaad C : J Neurosci, 2011
• Wnt/β-catenin signaling pathway is a direct enhancer of thyroid transcription factor-1 in human papillary thyroid carcinoma cells.
  Gilbert-Sirieix M, Makoukji J, Kimura S, Talbot M, Caillou B, Massaad C, Massaad-Massade L : PLoS One, 2011
• 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.
  Trousson A, Bernard S, Petit PX, Liere P, Pianos A, El Hadri K, Lobaccaro JM, Ghandour MS, Raymondjean M, Schumacher M, Massaad C : J Neurochem, 2009
• Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death.
  Trousson A, Makoukji J, Petit PX, Bernard S, Slomianny C, Schumacher M, Massaad C : PLoS One, 2009
• Hypoxia down-regulates CCAAT/enhancer binding protein-alpha expression in breast cancer cells.
  Seifeddine R, Dreiem A, Blanc E, Fulchignoni-Lataud MC, Le Frère Belda MA, Lecuru F, Mayi TH, Mazure N, Favaudon V, Massaad C, Barouki R, Massaad-Massade L : Cancer Res, 2008
• Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system.
  Schumacher M, Guennoun R, Ghoumari A, Massaad C, Robert F, El-Etr M, Akwa Y, Rajkowski K, Baulieu EE : Endocr Rev, 2007
• Opposite effects of CBP and p300 in glucocorticoid signaling in astrocytes.
  Fonte C, Trousson A, Grenier J, Schumacher M, Massaad C : J Steroid Biochem Mol Biol, 2007
• Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions.
  Trousson A, Grenier J, Fonte C, Massaad-Massade L, Schumacher M, Massaad C : J Steroid Biochem Mol Biol, 2007
• Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.
  Bordet T, Buisson B, Michaud M, Drouot C, Galéa P, Delaage P, Akentieva NP, Evers AS, Covey DF, Ostuni MA, Lacapère JJ, Massaad C, Schumacher M, Steidl EM, Maux D, Delaage M, Henderson CE, Pruss RM : J Pharmacol Exp Ther, 2007
• [Unusual mechanism of action and assembly of the glucocorticoid receptor and its coactivators in glial cells].
  Grenier J, Trousson A, Fonte C, Schumacher M, Massaad C : Med Sci (Paris), 2006
• Involvement of {beta}-catenin and unusual behavior of CBP and p300 in glucocorticosteroid signaling in Schwann cells.
  Fonte C, Grenier J, Trousson A, Chauchereau A, Lahuna O, Baulieu EE, Schumacher M, Massaad C : Proc Natl Acad Sci U S A, 2005