I am interested particularly in the dissection of the molecular mechanisms that control skeletal muscle development during mouse embryogenesis and adulthood. The roles played by protein-protein interactions in these processes are particularly exciting. We identified a new partner of NFAT transcription factors, the muscle specific bHLH protein MyoD. I would now love to define new coding and non coding partners for NFAT signaling components which are involved in skeletal myogenesis.

For many years, I have investigated the molecular mechanisms that control and regulate skeletal muscle differentiation in mice. The NFAT transcription factor family is particularly interesting since the knock out mice for NFATc2 and NFATc3 display distinct muscle phenotypes, muscle atrophy and aplasia, respectively. Indeed, these two transcription factors regulate different aspects of myogenesis by cooperating with other transcription factors. We demonstrated that these two NFAT isoforms are able to interact with a muscle specific transcription factor, MyoD. The NFAT/MyoD interaction controls different aspects of myogenesis, depending on the NFAT isoform involved in the interaction. This protein-protein interaction is crucial for NFATc3 to activate the expression of another muscle specific bHLH transcription factor, myogenin and, therefore, to regulate myogenic differentiation during early embryonic myogenesis in mice (Armand et al., 2008). The other NFAT isoform, NFATc2, also cooperates with MyoD. However, this interaction is involved in another step of myogenesis: the specification of myofibers during late embryonic myogenesis and neonatal development. Indeed, the NFATc2/MyoD complex regulates the expression of a fetal gene, the neonatal myosin heavy chain (neoMyHC) (Daou et al., 2013).

In collaboration with Leon de Windt, we showed the importance of microRNAs for the modulation of NFAT signaling in cardiac failure (da Costa Martins et al., 2010; Dirkx et al., 2013). We now are analyzing the microRNAs which might modulate NFATc2 signaling during skeletal myogenesis and we have started to envisage the functions of NFATc2 in determining the fates of muscle stem cells.

Recent Publications

Articles

• hTERT DNA Methylation Analysis Identifies a Biomarker for Retinoic Acid-Induced hTERT Repression in Breast Cancer Cell Lines.
  Nguyen E, Richerolle A, Sánchez-Bellver J, Varennes J, Ségal-Bendirdjian E : Biomedicines, 2022
• Obesity II: Establishing causal links between chemical exposures and obesity.
  Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G 3rd, Kassotis CD, Kay MK, Ji Kim M, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH, Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B : Biochem Pharmacol, 2022
• Merging the exposome into an integrated framework for
  Price EJ, Vitale CM, Miller GW, David A, Barouki R, Audouze K, Walker DI, Antignac JP, Coumoul X, Bessonneau V, Klánová J : IScience, 2022
• Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects.
  Brinkmann V, Romeo M, Larigot L, Hemmers A, Tschage L, Kleinjohann J, Schiavi A, Steinwachs S, Esser C, Menzel R, Giani Tagliabue S, Bonati L, Cox F, Ale-Agha N, Jakobs P, Altschmied J, Haendeler J, Coumoul X, Ventura N : Antioxidants (Basel), 2022
• Cytochromes P450 of : Implication in Biological Functions and Metabolism of Xenobiotics.
  Larigot L, Mansuy D, Borowski I, Coumoul X, Dairou J : Biomolecules, 2022
• Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway.
  D’Amico D, Biondi O, Januel C, Bezier C, Sapaly D, Clerc Z, El Khoury M, Sundaram VK, Houdebine L, Josse T, Della Gaspera B, Martinat C, Massaad C, Weill L, Charbonnier F : Neuropathol Appl Neurobiol, 2022
• [Endocrine disruptors : a discussed risk].
  Hill C, Barouki R, Audouze K, Coumoul X : Rev Prat, 2022
• TCDD aggravates the formation of the atherosclerotic plaque in ApoE KO mice with a sexual dimorphic pattern.
  Bey L, Coumoul X, Kim MJ : Biochimie, 2022
• Microbiome and metabolome features of the cardiometabolic disease spectrum.
  Fromentin S, Forslund SK, Chechi K, Aron-Wisnewsky J, Chakaroun R, Nielsen T, Tremaroli V, Ji B, Prifti E, Myridakis A, Chilloux J, Andrikopoulos P, Fan Y, Olanipekun MT, Alves R, Adiouch S, Bar N, Talmor-Barkan Y, Belda E, Caesar R, Coelho LP, Falony G, Fellahi S, Galan P, Galleron N, Helft G, Hoyles L, Isnard R, Le Chatelier E, Julienne H, Olsson L, Pedersen HK, Pons N, Quinquis B, Rouault C, Roume H, Salem JE, Schmidt TSB, Vieira-Silva S, Li P, Zimmermann-Kogadeeva M, Lewinter C, Søndertoft NB, Hansen TH, Gauguier D, Gøtze JP, Køber L, Kornowski R, Vestergaard H, Hansen T, Zucker JD, Hercberg S, Letunic I, Bäckhed F, Oppert JM, Nielsen J, Raes J, Bork P, Stumvoll M, Segal E, Clément K, Dumas ME, Ehrlich SD, Pedersen O : Nat Med, 2022
• T cell apoptosis characterizes severe Covid-19 disease.
  André S, Picard M, Cezar R, Roux-Dalvai F, Alleaume-Butaux A, Soundaramourty C, Cruz AS, Mendes-Frias A, Gotti C, Leclercq M, Nicolas A, Tauzin A, Carvalho A, Capela C, Pedrosa J, Castro AG, Kundura L, Loubet P, Sotto A, Muller L, Lefrant JY, Roger C, Claret PG, Duvnjak S, Tran TA, Racine G, Zghidi-Abouzid O, Nioche P, Silvestre R, Droit A, Mammano F, Corbeau P, Estaquier J : Cell Death Differ, 2022
• [What is known about the action of endocrine disruptors on the immune system?]
  Estaquier J, Blanc É, Coumoul X : Rev Prat, 2021
• Lentiviral Infections Persist in Brain despite Effective Antiretroviral Therapy and Neuroimmune Activation.
  Mohammadzadeh N, Roda W, Branton WG, Clain J, Rabezanahary H, Zghidi-Abouzid O, Gelman BB, Angel JB, Cohen EA, Gill MJ, Li M, Estaquier J, Power C : MBio, 2021
• Immune-metabolic interactions between Leishmania and macrophage host.
  Ferreira C, Estaquier J, Silvestre R : Curr Opin Microbiol, 2021
• The Modulation of NADPH Oxidase Activity in Human Neutrophils by Moroccan Strains of and Is Not Associated with p47 Phosphorylation.
  Maksouri H, Darif D, Estaquier J, Riyad M, Desterke C, Lemrani M, Dang PM, Akarid K : Microorganisms, 2021
• Mitochondrial Dysfunction as a Hallmark of Environmental Injury.
  Duarte-Hospital C, Tête A, Brial F, Benoit L, Koual M, Tomkiewicz C, Kim MJ, Blanc EB, Coumoul X, Bortoli S : Cells, 2021
• The exposome and toxicology: a win-win collaboration.
  Barouki R, Audouze K, Becker C, Blaha L, Coumoul X, Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D : Toxicol Sci, 2021
• Development of a chemogenomics library for phenotypic screening.
  Dafniet B, Cerisier N, Boezio B, Clary A, Ducrot P, Dorval T, Gohier A, Brown D, Audouze K, Taboureau O : J Cheminform, 2021
• Development of a chemogenomics library for phenotypic screening.
  Dafniet B, Cerisier N, Boezio B, Clary A, Ducrot P, Dorval T, Gohier A, Brown D, Audouze K, Taboureau O : J Cheminform, 2021
• The exposome and toxicology: a win-win collaboration.
  Barouki R, Audouze K, Becker C, Blaha L, Coumoul X, Karakitsios S, Klanova J, Miller GW, Price EJ, Sarigiannis D : Toxicol Sci, 2021
• The GhsrQ343X allele favors the storage of fat by acting on nutrient partitioning.
  Marion C, Zizzari P, Denis RG, Hassouna R, Chebani Y, Leste-Lasserre T, Doat H, Le Pen G, Cota D, Noble F, Luquet S, Pantel J : J Endocrinol, 2021
• Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex.
  Correia MJ, Pimpão AB, Lopes-Coelho F, Sequeira CO, Coelho NR, Gonçalves-Dias C, Barouki R, Coumoul X, Serpa J, Morello J, Monteiro EC, Pereira SA : Antioxidants (Basel), 2021
• Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor.
  Larigot L, Benoit L, Koual M, Tomkiewicz C, Barouki R, Coumoul X : Annu Rev Pharmacol Toxicol, 2021
• The association between environmental exposures to chlordanes, adiposity and diabetes-related features: a systematic review and meta-analysis.
  Mendes V, Ribeiro C, Delgado I, Peleteiro B, Aggerbeck M, Distel E, Annesi-Maesano I, Sarigiannis D, Ramos E : Sci Rep, 2021
• Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema.
  Margaritte-Jeannin P, Budu-Aggrey A, Ege M, Madore AM, Linhard C, Mohamdi H, von Mutius E, Granell R, Demenais F, Laprise C, Bouzigon E, Dizier MH : Clin Exp Allergy, 2021
• Mechanical loading activates the YAP/TAZ pathway and chemokine expression in the MLO-Y4 osteocyte-like cell line.
  Zarka M, Etienne F, Bourmaud M, Szondi D, Schwartz JM, Kampmann K, Helary C, Rannou F, Haÿ E, Cohen-Solal M : Lab Invest, 2021
• The COVID-19 pandemic and global environmental change: Emerging research needs.
  Barouki R, Kogevinas M, Audouze K, Belesova K, Bergman A, Birnbaum L, Boekhold S, Denys S, Desseille C, Drakvik E, Frumkin H, Garric J, Destoumieux-Garzon D, Haines A, Huss A, Jensen G, Karakitsios S, Klanova J, Koskela IM, Laden F, Marano F, Franziska Matthies-Wiesler E, Morris G, Nowacki J, Paloniemi R, Pearce N, Peters A, Rekola A, Sarigiannis D, Šebková K, Slama R, Staatsen B, Tonne C, Vermeulen R, Vineis P, HERA-COVID-19 working group Electronic address: https://wwwheraresearcheueu/ : Environ Int, 2021
• Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs.
  Street ME, Audouze K, Legler J, Sone H, Palanza P : Int J Mol Sci, 2021
• Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways.
  Hernandez I, Chissey A, Guibourdenche J, Atasoy R, Coumoul X, Fournier T, Beaudeux JL, Zerrad-Saadi A : Antioxidants (Basel), 2021
• Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged.
  Ahmed S, Salmon H, Distasio N, Do HD, Scherman D, Alhareth K, Tabrizian M, Mignet N : Pharmaceutics, 2021
• Lack of Skeletal Muscle Serotonin Impairs Physical Performance.
  Falabrègue M, Boschat AC, Jouffroy R, Derquennes M, Djemai H, Sanquer S, Barouki R, Coumoul X, Toussaint JF, Hermine O, Noirez P, Côté F : Int J Tryptophan Res, 2021
• Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.
  Brial F, Chilloux J, Nielsen T, Vieira-Silva S, Falony G, Andrikopoulos P, Olanipekun M, Hoyles L, Djouadi F, Neves AL, Rodriguez-Martinez A, Mouawad GI, Pons N, Forslund S, Le-Chatelier E, Le Lay A, Nicholson J, Hansen T, Hyötyläinen T, Clément K, Oresic M, Bork P, Ehrlich SD, Raes J, Pedersen OB, Gauguier D, Dumas ME : Gut, 2021
• Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration.
  Zgheib E, Kim MJ, Jornod F, Bernal K, Tomkiewicz C, Bortoli S, Coumoul X, Barouki R, De Jesus K, Grignard E, Hubert P, Katsanou ES, Busquet F, Audouze K : Environ Int, 2021
• Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence.
  Matta K, Koual M, Ploteau S, Coumoul X, Audouze K, Le Bizec B, Antignac JP, Cano-Sancho G : Environ Health Perspect, 2021
• RALDH Activity Induced by Bacterial/Fungal Pathogens in CD16 Monocyte-Derived Dendritic Cells Boosts HIV Infection and Outgrowth in CD4 T Cells.
  Cattin A, Wacleche VS, Fonseca Do Rosario N, Marchand LR, Dias J, Gosselin A, Cohen EA, Estaquier J, Chomont N, Routy JP, Ancuta P : J Immunol, 2021
• Differential Inhibition of HIV Replication by the 12 Interferon Alpha Subtypes.
  Tauzin A, Espinosa Ortiz A, Blake O, Soundaramourty C, Joly-Beauparlant C, Nicolas A, Droit A, Dutrieux J, Estaquier J, Mammano F : J Virol, 2021
• Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy.
  Meziane O, Alexandrova Y, Olivenstein R, Dupuy FP, Salahuddin S, Thomson E, Orlova M, Schurr E, Ancuta P, Durand M, Chomont N, Estaquier J, Bernard NF, Costiniuk CT, Jenabian MA : J Immunol, 2021
• Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis.
  Carrete A, Padilla-Ferrer A, Simon A, Meffre D, Jafarian-Tehrani M : Neuroscience, 2021
• Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein.
  Calcagnile M, Forgez P, Iannelli A, Bucci C, Alifano M, Alifano P : Biochimie, 2021
• The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response.
  Icard P, Lincet H, Wu Z, Coquerel A, Forgez P, Alifano M, Fournel L : Biochimie, 2021
• AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency.
  Karmouch J, Delers P, Semprez F, Soyed N, Areias J, Bélanger G, Ravel-Chapuis A, Dobbertin A, Jasmin BJ, Legay C : Front Mol Neurosci, 2020
• Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice.
  Eid SA, El Massry M, Hichor M, Haddad M, Grenier J, Dia B, Barakat R, Boutary S, Chanal J, Aractingi S, Wiesel P, Szyndralewiez C, Azar ST, Boitard C, Zaatari G, Eid AA, Massaad C : Diabetes, 2020
• Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions.
  Russick J, Joubert PE, Gillard-Bocquet M, Torset C, Meylan M, Petitprez F, Dragon-Durey MA, Marmier S, Varthaman A, Josseaume N, Germain C, Goc J, Dieu-Nosjean MC, Validire P, Fournel L, Zitvogel L, Bindea G, Lupo A, Damotte D, Alifano M, Cremer I : J Immunother Cancer, 2020
• Age-dependent vulnerability of the ovary to AhR-mediated TCDD action before puberty: Evidence from mouse models.
  Devillers MM, Petit F, Giton F, François CM, Juricek L, Coumoul X, Magre S, Cohen-Tannoudji J, Guigon CJ : Chemosphere, 2020
• Environmental chemicals, breast cancer progression and drug resistance.
  Koual M, Tomkiewicz C, Cano-Sancho G, Antignac JP, Bats AS, Coumoul X : Environ Health, 2020
• Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma.
  Li B, Li Y, Tomkiewicz-Raulet C, Dao P, Lietha D, Yen-Pon E, Du Z, Coumoul X, Garbay C, Etheve-Quelquejeu M, Chen H : J Med Chem, 2020
• Aging Cartilage in Wild-Type Mice: An Observational Study.
  Akoum J, Tahiri K, Corvol MT, Borderie D, Étienne F, Rannou F, Nguyen C : Cartilage, 2020
• Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach.
  Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K : MedRxiv, 2020
• Pathogenesis and therapeutic targets in spinal muscular atrophy (SMA).
  Lefebvre S, Sarret C : Arch Pediatr, 2020
• The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases.
  Sapaly D, Delers P, Coridon J, Salman B, Letourneur F, Dumont F, Lefebvre S : Front Mol Biosci, 2020
• Non-human primates and immunity.
  André S, Rodrigues V, Picard M, Silvestre R, Estaquier J : Cytokine X, 2020
• Cytokines and metabolic regulation: A framework of bidirectional influences affecting Leishmania infection.
  Bodhale N, Ohms M, Ferreira C, Mesquita I, Mukherjee A, André S, Sarkar A, Estaquier J, Laskay T, Saha B, Silvestre R : Cytokine, 2020
• Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques.
  Rabezanahary H, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Borde C, Mammano F, Mesplèdes T, Ancuta P, Zghidi-Abouzid O, Estaquier J : J Virol, 2020
• Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
  Rabezanahary H, Moukambi F, Palesch D, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Zghidi-Abouzid O, Soundaramourty C, Tremblay C, Silvestri G, Estaquier J : Mucosal Immunol, 2020
• Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.
  Ferreira C, Mesquita I, Barbosa AM, Osório NS, Torrado E, Beauparlant CJ, Droit A, Cunha C, Carvalho A, Saha B, Estaquier J, Silvestre R : PLoS Negl Trop Dis, 2020
• The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis.
  Mesquita I, Ferreira C, Moreira D, Kluck GEG, Barbosa AM, Torrado E, Dinis-Oliveira RJ, Gonçalves LG, Beauparlant CJ, Droit A, Berod L, Sparwasser T, Bodhale N, Saha B, Rodrigues F, Cunha C, Carvalho A, Castro AG, Estaquier J, Silvestre R : Cell Rep, 2020
• Antileishmanial Drugs Modulate IL-12 Expression and Inflammasome Activation in Primary Human Cells.
  André S, Rodrigues V, Pemberton S, Laforge M, Fortier Y, Cordeiro-da-Silva A, MacDougall J, Estaquier J : J Immunol, 2020
• Complex context-relationships between DNA methylation and accessibility, histone marks, and hTERT gene expression in acute promyelocytic leukemia cells: perspectives for all-trans retinoic acid (ATRA) in cancer therapy.
  Garsuault D, Bouyer C, Nguyen E, Kandhari R, Prochazkova-Carlotti M, Chevret E, Forgez P, Ségal-Bendirdjian E : Mol Oncol, 2020
• Computational systems biology as an animal-free approach to characterize toxicological effects of persistent organic pollutants.
  Wu Q, Achebouche R, Audouze K : ALTEX, 2020
• Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches.
  Rugard M, Coumoul X, Carvaillo JC, Barouki R, Audouze K : Toxicol Sci, 2020
• Impact of hepatitis C virus and alcohol, alone and combined, on the unfolded protein response in primary human hepatocytes.
  Hernandez C, Blanc EB, Pène V, Le-Grand B, Villaret M, Aoudjehane L, Carpentier A, Conti F, Calmus Y, Podevin P, Garlatti M, Rouach H, Rosenberg AR : Biochimie, 2020
• Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells.
  Bénit P, Kahn A, Chretien D, Bortoli S, Huc L, Schiff M, Gimenez-Roqueplo AP, Favier J, Gressens P, Rak M, Rustin P : PLoS One, 2019
• Mucosal T follicular helper cells in SIV-infected rhesus macaques: contributing role of IL-27.
  Moukambi F, Rabezanahary H, Fortier Y, Rodrigues V, Clain J, Benmadid-Laktout G, Zghidi-Abouzid O, Soundaramourty C, Laforge M, Estaquier J : Mucosal Immunol, 2019
• Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
  Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA : J Virol, 2019
• Transcriptional Analysis of Human Skin Lesions Identifies Tryptophan-2,3-Deoxygenase as a Restriction Factor for Cutaneous .
  Rodrigues V, André S, Maksouri H, Mouttaki T, Chiheb S, Riyad M, Akarid K, Estaquier J : Front Cell Infect Microbiol, 2019
• Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform.
  Laliberté-Gagné MÈ, Bolduc M, Thérien A, Garneau C, Casault P, Savard P, Estaquier J, Leclerc D : Vaccines (Basel), 2019
• Serotonin in stem cell based-dental repair and bone formation: A review.
  Baudry A, Schneider B, Launay JM, Kellermann O : Biochimie, 2019
• Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.
  Baudry A, Pietri M, Launay JM, Kellermann O, Schneider B : Front Neurosci, 2019
• Production of seedable Amyloid-β peptides in model of prion diseases upon PrP-induced PDK1 overactivation.
  Ezpeleta J, Baudouin V, Arellano-Anaya ZE, Boudet-Devaud F, Pietri M, Baudry A, Haeberlé AM, Bailly Y, Kellermann O, Launay JM, Schneider B : Nat Commun, 2019
• Effects of Single Cage Housing on Stress, Cognitive, and Seizure Parameters in the Rat and Mouse Pilocarpine Models of Epilepsy.
  Manouze H, Ghestem A, Poillerat V, Bennis M, Ba-M’hamed S, Benoliel JJ, Becker C, Bernard C : ENeuro, 2019
• Preclinical Evaluation of Ga-DOTA-NT-20.3: A Promising PET Imaging Probe To Discriminate Human Pancreatic Ductal Adenocarcinoma from Pancreatitis.
  Prignon A, Provost C, Alshoukr F, Wendum D, Couvelard A, Barbet J, Forgez P, Talbot JN, Gruaz-Guyon A : Mol Pharm, 2019
• Cisplatin increases PD-L1 expression and optimizes immune check-point blockade in non-small cell lung cancer.
  Fournel L, Wu Z, Stadler N, Damotte D, Lococo F, Boulle G, Ségal-Bendirdjian E, Bobbio A, Icard P, Trédaniel J, Alifano M, Forgez P : Cancer Lett, 2019
• sAOP: linking chemical stressors to adverse outcomes pathway networks.
  Aguayo-Orozco A, Audouze K, Siggaard T, Barouki R, Brunak S, Taboureau O : Bioinformatics, 2019
• Applying a Virtual Reality Platform in Environmental Chemistry Education To Conduct a Field Trip to an Overseas Site.
  Blanc E : J Med Chem, 2019
• A dual mixture of persistent organic pollutants modifies carbohydrate metabolism in the human hepatic cell line HepaRG.
  Leblanc AF, Attignon EA, Distel E, Karakitsios SP, Sarigiannis DA, Bortoli S, Barouki R, Coumoul X, Aggerbeck M, Blanc EB : Environ Res, 2019
• The age-performance relationship in the general population and strategies to delay age related decline in performance.
  Berthelot G, Johnson S, Noirez P, Antero J, Marck A, Desgorces FD, Pifferi F, Carter PA, Spedding M, Manoux AS, Toussaint JF : Arch Public Health, 2019
• KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.
  Goutierre M, Al Awabdh S, Donneger F, François E, Gomez-Dominguez D, Irinopoulou T, Menendez de la Prida L, Poncer JC : Cell Rep, 2019
• Microplastic freshwater contamination: an issue advanced by science with public engagement.
  Allen B, Coumoul X, Lacorte S : Environ Sci Pollut Res Int, 2019
• A forum where french-speaking faculty can exchange research on teaching.
  Vicens Q, Coumoul X, Souciet JL : Biochem Mol Biol Educ, 2019
• Morphine-Induced Dendritic Spine Remodeling in Rat Nucleus Accumbens Is Corticosterone Dependent.
  Geoffroy H, Canestrelli C, Marie N, Noble F : Int J Neuropsychopharmacol, 2019
• Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.
  Carvaillo JC, Barouki R, Coumoul X, Audouze K : Environ Health Perspect, 2019
• Spontaneous resurgence of conditioned fear weeks after successful extinction in brain injured mice.
  Corne R, Leconte C, Ouradou M, Fassina V, Zhu Y, Déou E, Besson V, Plotkine M, Marchand-Leroux C, Mongeau R : Prog Neuropsychopharmacol Biol Psychiatry, 2019
• Increased 5-HT2C receptor editing predisposes to PTSD-like behaviors and alters BDNF and cytokines signaling.
  Règue M, Poilbout C, Martin V, Franc B, Lanfumey L, Mongeau R : Transl Psychiatry, 2019
• Synchronous Oligometastatic Lung Cancer Deserves a Dedicated Management.
  Loi M, Mazzella A, Mansuet-Lupo A, Bobbio A, Canny E, Magdeleinat P, Régnard JF, Damotte D, Trédaniel J, Alifano M : Ann Thorac Surg, 2019
• Endogenous multidien rhythm of epilepsy in rats.
  Baud MO, Ghestem A, Benoliel JJ, Becker C, Bernard C : Exp Neurol, 2019
• Antioxidant treatment after epileptogenesis onset prevents comorbidities in rats sensitized by a past stressful event.
  Becker C, Mancic A, Ghestem A, Poillerat V, Claverie D, Bartolomei F, Brouillard F, Benoliel JJ, Bernard C : Epilepsia, 2019
• Detection of pretreatment minority HIV-1 reverse transcriptase inhibitor-resistant variants by ultra-deep sequencing has a limited impact on virological outcomes.
  Su B, Zheng X, Liu Y, Liu L, Xin R, Lu H, Huang C, Bai L, Mammano F, Zhang T, Wu H, Sun L, Dai L : J Antimicrob Chemother, 2019
• Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men.
  Jiang L, Audouze K, Romero Herrera JA, Ängquist LH, Kjærulff SK, Izarzugaza JMG, Tjønneland A, Halkjær J, Overvad K, Sørensen TIA, Brunak S : Clin Nutr, 2019
• Modulation of lung cancer cell plasticity and heterogeneity with the restoration of cisplatin sensitivity by neurotensin antibody.
  Wu Z, Fournel L, Stadler N, Liu J, Boullier A, Hoyeau N, Fléjou JF, Duchatelle V, Djebrani-Oussedik N, Agopiantz M, Ségal-Bendirdjian E, Gompel A, Alifano M, Melander O, Trédaniel J, Forgez P : Cancer Lett, 2019
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• Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment.
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• 5-HT2C receptor desensitization moderates anxiety in 5-HTT deficient mice: from behavioral to cellular evidence.
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• Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/β-catenin and Akt/CREB pathways.
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• Temporal regulation of peripheral BDNF levels during cocaine and morphine withdrawal: comparison with a natural reward.
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• Lipids in metabolic diseases.
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• Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers.
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• A PrP(C)-caveolin-Lyn complex negatively controls neuronal GSK3β and serotonin 1B receptor.
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• Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross-sectional survey.
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• Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case-control study in Guadeloupe (French West Indies).
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• Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites.
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• Influence of cocaine administration patterns on dopamine receptor regulation.
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• Rewarding or aversive effects of buprenorphine/naloxone combination (Suboxone) depend on conditioning trial duration.
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• Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties.
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• Striatal dopamine D1 and D2 receptors are differentially regulated following buprenorphine or methadone treatment.
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• Opioid receptor desensitization: mechanisms and its link to tolerance.
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• High-protein-low-carbohydrate diet: deleterious metabolic and cardiovascular effects depend on age.
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• Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice.
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• Detection of vascular cell adhesion molecule-1 expression with USPIO-enhanced molecular MRI in a mouse model of cerebral ischemia.
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• Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice.
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• Short-term outcome of patients with preeclampsia.
  Koual M, Abbou H, Carbonnel M, Picone O, Ayoubi JM : Vasc Health Risk Manag, 2013
• RNA splicing and editing modulation of 5-HT(2C) receptor function: relevance to anxiety and aggression in VGV mice.
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• ChemProt-2.0: visual navigation in a disease chemical biology database.
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• HExpoChem: a systems biology resource to explore human exposure to chemicals.
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• The effect of network biology on drug toxicology.
  Gautier L, Taboureau O, Audouze K : Expert Opin Drug Metab Toxicol, 2013
• A computational approach to chemical etiologies of diabetes.
  Audouze K, Brunak S, Grandjean P : Sci Rep, 2013
• CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice.
  Lopez-Rodriguez AB, Siopi E, Finn DP, Marchand-Leroux C, Garcia-Segura LM, Jafarian-Tehrani M, Viveros MP : Cereb Cortex, 2013
• Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure.
  Dirkx E, Gladka MM, Philippen LE, Armand AS, Kinet V, Leptidis S, El Azzouzi H, Salic K, Bourajjaj M, da Silva GJ, Olieslagers S, van der Nagel R, de Weger R, Bitsch N, Kisters N, Seyen S, Morikawa Y, Chanoine C, Heymans S, Volders PG, Thum T, Dimmeler S, Cserjesi P, Eschenhagen T, da Costa Martins PA, De Windt LJ : Nat Cell Biol, 2013
• Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells.
  Branchu J, Biondi O, Chali F, Collin T, Leroy F, Mamchaoui K, Makoukji J, Pariset C, Lopes P, Massaad C, Chanoine C, Charbonnier F : J Neurosci, 2013
• Wnt and lithium: a common destiny in the therapy of nervous system pathologies?
  Meffre D, Grenier J, Bernard S, Courtin F, Dudev T, Shackleford G, Jafarian-Tehrani M, Massaad C : Cell Mol Life Sci, 2013
• Pathogenic role of basic calcium phosphate crystals in destructive arthropathies.
  Ea HK, Chobaz V, Nguyen C, Nasi S, van Lent P, Daudon M, Dessombz A, Bazin D, McCarthy G, Jolles-Haeberli B, Ives A, Van Linthoudt D, So A, Lioté F, Busso N : PLoS One, 2013
• Revisiting spatial distribution and biochemical composition of calcium-containing crystals in human osteoarthritic articular cartilage.
  Nguyen C, Bazin D, Daudon M, Chatron-Colliet A, Hannouche D, Bianchi A, Côme D, So A, Busso N, Busso N, Lioté F, Ea HK : Arthritis Res Ther, 2013
• Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo.
  Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, Curtis C, Skoczylas R, Davidson TL, Miura N, Hong YK, Koopman P, Harvey NL, François M : Dev Biol, 2013
• The status of strontium in biological apatites: an XANES/EXAFS investigation.
  Bazin D, Dessombz A, Nguyen C, Ea HK, Lioté F, Rehr J, Chappard C, Rouzière S, Thiaudière D, Reguer S, Daudon M : J Synchrotron Radiat, 2013
• A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.
  Daou N, Lecolle S, Lefebvre S, della Gaspera B, Charbonnier F, Chanoine C, Armand AS : Development, 2013
• Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes.
  Shackleford G, Makoukji J, Grenier J, Liere P, Meffre D, Massaad C : Biochem Pharmacol, 2013
• The activation of the WNT signaling pathway is a Hallmark in neurofibromatosis type 1 tumorigenesis.
  Luscan A, Shackleford G, Masliah-Planchon J, Laurendeau I, Ortonne N, Varin J, Lallemand F, Leroy K, Dumaine V, Hivelin M, Borderie D, De Raedt T, Valeyrie-Allanore L, Larousserie F, Terris B, Lantieri L, Vidaud M, Vidaud D, Wolkenstein P, Parfait B, Bièche I, Massaad C, Pasmant E : Clin Cancer Res, 2013
• Synapto-protective drugs evaluation in reconstructed neuronal network.
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• PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer\\’s diseases.
  Pietri M, Dakowski C, Hannaoui S, Alleaume-Butaux A, Hernandez-Rapp J, Ragagnin A, Mouillet-Richard S, Haik S, Bailly Y, Peyrin JM, Launay JM, Kellermann O, Schneider B : Nat Med, 2013
• Deletion of serotonin 2B receptor provokes structural alterations of mouse dental tissues.
  Dimitrova-Nakov S, Baudry A, Harichane Y, Collet C, Marchadier A, Kellermann O, Goldberg M : Calcif Tissue Int, 2013
• Development and validation of a questionnaire assessing fears and beliefs of patients with knee osteoarthritis: the Knee Osteoarthritis Fears and Beliefs Questionnaire (KOFBeQ).
  Benhamou M, Baron G, Dalichampt M, Boutron I, Alami S, Rannou F, Ravaud P, Poiraudeau S : PLoS One, 2013
• Animal evidence for hyaluronic acid efficacy in knee trauma injuries. Review of animal-model studies.
  Edouard P, Rannou F, Coudeyre E : Phys Ther Sport, 2013
• [Physical therapy, orthosis and occupational therapy in medical and surgical rheumatologic hand diseases].
  Dumitrache A, Sanchez K, Esnouf S, Roren A, Vidal J, Rannou F, Poiraudeau S, Lefèvre-Colau MM : Presse Med, 2013
• Early-life prevention of non-communicable diseases.
  Balbus JM, Barouki R, Birnbaum LS, Etzel RA, Gluckman PD, Grandjean P, Hancock C, Hanson MA, Heindel JJ, Hoffman K, Jensen GK, Keeling A, Neira M, Rabadán-Diehl C, Ralston J, Tang KC : Lancet, 2013
• [Environment and health: the lessons of pesticides].
  Barouki R : Med Sci (Paris), 2013
• [Can xenobiotics accumulated in adipose tissue contribute to a carcinogenic risk?].
  Barouki R : Ann Endocrinol (Paris), 2013
• Viewing drug action as network perturbation in multiple scale systems.
  Barouki R : Drug Metabol Drug Interact, 2013
• Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin.
  Pierre S, Chevallier A, Teixeira-Clerc F, Ambolet-Camoit A, Bui LC, Bats AS, Fournet JC, Fernandez-Salguero P, Aggerbeck M, Lotersztajn S, Barouki R, Coumoul X : Toxicol Sci, 2013
• Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.
  Janin M, Mylonas E, Saada V, Micol JB, Renneville A, Quivoron C, Koscielny S, Scourzic L, Forget S, Pautas C, Caillot D, Preudhomme C, Dombret H, Berthon C, Barouki R, Rabier D, Auger N, Griscelli F, Chachaty E, Leclercq E, Courtier MH, Bennaceur-Griscelli A, Solary E, Bernard OA, Penard-Lacronique V, Ottolenghi C, de Botton S : J Clin Oncol, 2013
• Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts.
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• Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice.
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• Comparison of the transcriptional responses induced by acute morphine, methadone and buprenorphine.
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• Oculomotor deficits in aryl hydrocarbon receptor null mouse.
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• Expression of calcineurin activity after lung transplantation: a 2-year follow-up.
  Sanquer S, Amrein C, Grenet D, Guillemain R, Philippe B, Boussaud V, Herry L, Lena C, Diouf A, Paunet M, Billaud EM, Loriaux F, Jais JP, Barouki R, Stern M : PLoS One, 2013
• Early-life prevention of non-communicable diseases
  Balbus JM, Barouki R, Birnbaum LS, Etzel RA, Gluckman PD, Grandjean P, Hancock C, Hanson MA, Heindel JJ, Hoffman K, Jensen G, Keeling A, Neira M, Rabadan-Diehl C, Ralston J, Tang KC : Lancet, 2013
• HIV cell-to-cell transmission requires the production of infectious virus particles and does not proceed through env-mediated fusion pores.
  Monel B, Beaumont E, Vendrame D, Schwartz O, Brand D, Mammano F : J Virol, 2012
• A new vesicular scaffolding complex mediates the G-protein-coupled 5-HT1A receptor targeting to neuronal dendrites.
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• Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain adrenomedullin gene expression.
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• Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures.
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• [G-protein-coupled receptors targeting: the allosteric approach].
  Sebag JA, Pantel J : Med Sci (Paris), 2012
• Evaluation of late cognitive impairment and anxiety states following traumatic brain injury in mice: the effect of minocycline.
  Siopi E, Llufriu-Dabén G, Fanucchi F, Plotkine M, Marchand-Leroux C, Jafarian-Tehrani M : Neurosci Lett, 2012
• Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice.
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• A head and neck cancer tumor response-specific gene signature for cisplatin, 5-fluorouracil induction chemotherapy fails with added taxanes.
  Tomkiewicz C, Hans S, Mucchielli MH, Agier N, Delacroix H, Marisa L, Brasnu D, Aggerbeck LP, Badoual C, Barouki R, Aggerbeck M : PLoS One, 2012
• A role for protein phosphatase PP1γ in SMN complex formation and subnuclear localization to Cajal bodies.
  Renvoisé B, Quérol G, Verrier ER, Burlet P, Lefebvre S : J Cell Sci, 2012
• Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.
  Piazzon N, Schlotter F, Lefebvre S, Dodré M, Méreau A, Soret J, Besse A, Barkats M, Bordonné R, Branlant C, Massenet S : Nucleic Acids Res, 2012
• Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity.
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• Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia.
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• Wnt4 participates in the formation of vertebrate neuromuscular junction.
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• Rapid nitration of adipocyte phosphoenolpyruvate carboxykinase by leptin reduces glyceroneogenesis and induces fatty acid release.
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• A novel function for the survival motoneuron protein as a translational regulator.
  Sanchez G, Dury AY, Murray LM, Biondi O, Tadesse H, El Fatimy R, Kothary R, Charbonnier F, Khandjian EW, Côté J : Hum Mol Genet, 2012
• Mef2d acts upstream of muscle identity genes and couples lateral myogenesis to dermomyotome formation in Xenopus laevis.
  Della Gaspera B, Armand AS, Lecolle S, Charbonnier F, Chanoine C : PLoS One, 2012
• Lithium enhances remyelination of peripheral nerves.
  Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C : Proc Natl Acad Sci U S A, 2012
• Hyperthermia stimulates HIV-1 replication.
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• Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected mice.
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• Picosecond to second dynamics reveals a structural transition in Clostridium botulinum NO-sensor triggered by the activator BAY-41-2272.
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• A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis.
  Berenbaum F, Grifka J, Cazzaniga S, D\\’Amato M, Giacovelli G, Chevalier X, Rannou F, Rovati LC, Maheu E : Ann Rheum Dis, 2012
• Hypoxia induces nitric oxide synthase in rheumatoid synoviocytes: consequences on NADPH oxidase regulation.
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• First combined in vivo X-ray tomography and high-resolution molecular electron paramagnetic resonance (EPR) imaging of the mouse knee joint taking into account the disappearance kinetics of the EPR probe.
  Bézière N, Decroos C, Mkhitaryan K, Kish E, Richard F, Bigot-Marchand S, Durand S, Cloppet F, Chauvet C, Corvol MT, Rannou F, Xu-Li Y, Mansuy D, Peyrot F, Frapart YM : Mol Imaging, 2012
• Elaboration and validation of a questionnaire assessing patient expectations about management of knee osteoarthritis by their physicians: the Knee Osteoarthritis Expectations Questionnaire.
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• [Prescribe non-pharmacological treatments for lower limb osteoarthritis?].
  Rannou F : Rev Prat, 2012
• The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway.
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• PPTOX III: environmental stressors in the developmental origins of disease--evidence and mechanisms.
  Schug TT, Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ : Toxicol Sci, 2012
• Transfer of neuroplasticity from nucleus accumbens core to shell is required for cocaine reward.
  Marie N, Canestrelli C, Noble F : PLoS One, 2012
• In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile.
  Faget L, Erbs E, Le Merrer J, Scherrer G, Matifas A, Benturquia N, Noble F, Decossas M, Koch M, Kessler P, Vonesch JL, Schwab Y, Kieffer BL, Massotte D : J Neurosci, 2012
• [Drug dependence: Progress in neurobiology and perspectives in therapeutics].
  Marie N, Noble F : Presse Med, 2012
• Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice.
  Allouche S, Le Marec T, Noble F, Marie N : Prog Neuropsychopharmacol Biol Psychiatry, 2012
• Wnt4 participates in the formation of vertebrate neuromuscular junction
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• Myogenic waves and myogenic programs during Xenopus embryonic myogenesis.
  Della Gaspera B, Armand AS, Sequeira I, Chesneau A, Mazabraud A, Lécolle S, Charbonnier F, Chanoine C : Dev Dyn, 2012
• Physical exercise reduces cardiac defects in type 2 spinal muscular atrophy-like mice.
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• Mef2d acts upstream of muscle identity genes and couples lateral myogenesis to dermomyotome formation in Xenopus laevis.
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• Updated follow-up of patients treated with the oncoplastic Crescent technique for breast cancer.
  Aljarrah A, Nos C, Nasr R, Clough KB, Bats AS, Lecuru F : Breast, 2012
• The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications.
  Guyot E, Chevallier A, Barouki R, Coumoul X : Drug Discov Today, 2012
• Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants.
  La Merrill M, Emond C, Kim MJ, Antignac JP, Le Bizec B, Clément K, Birnbaum LS, Barouki R : Environ Health Perspect, 2012
• A head and neck cancer tumor response-specific gene signature for Cisplatin, 5-Fluorouracil induction chemotherapy fails with added taxanes.
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• The AhR regulates focal adhesion sites through a non-genomic FAK/Src pathway.
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• PPTOX III: Environmental Stressors in the Developmental Origins of Disease: Evidence and Mechanisms.
  Schug TT, Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ : Toxicol Sci, 2012
• Is there NO help for leptin?
  Joffin N, Niang F, Forest C, Jaubert AM : Biochimie, 2012
• Rapid nitration of adipocyte phosphoenolpyruvate carboxykinase by leptin reduces glyceroneogenesis and induces fatty acid release
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• Early induction of a brown-like phenotype by rosiglitazone in the epicardial adipose tissue of fatty Zucker rats.
  Distel E, Penot G, Cadoudal T, Balguy I, Durant S, Benelli C : Biochimie, 2012
• Developmental origins of non-communicable disease: implications for research and public health.
  Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ : Environ Health, 2012
• The aryl hydrocarbon receptor system.
  Barouki R, Aggerbeck M, Aggerbeck L, Coumoul X : Drug Metabol Drug Interact, 2012
• A comparison of two human cell lines and two rat gonadal cell primary cultures as in vitro screening tools for aromatase modulation.
  Quignot N, Desmots S, Barouki R, Lemazurier E : Toxicol In Vitro, 2012
• Lipids in all their states.
  Forest C : Biochimie, 2012
• Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.
  Guyot E, Coumoul X, Chassé JF, Khallouki F, Savouret JF, Poirot M, Barouki R : Biochem Pharmacol, 2012
• Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells.
  Kim MJ, Pelloux V, Guyot E, Tordjman J, Bui LC, Chevallier A, Forest C, Benelli C, Clément K, Barouki R : Environ Health Perspect, 2012
• Characterization of endocrine-disrupting chemicals based on hormonal balance disruption in male and female adult rats.
  Quignot N, Arnaud M, Robidel F, Lecomte A, Tournier M, Cren-Olivé C, Barouki R, Lemazurier E : Reprod Toxicol, 2012
• Quantification of steroids and endocrine disrupting chemicals in rat ovaries by LC-MS/MS for reproductive toxicology assessment.
  Quignot N, Tournier M, Pouech C, Cren-Olivé C, Barouki R, Lemazurier E : Anal Bioanal Chem, 2012
• Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. (PDF)
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• Cost-effective multiplexing before capture allows screening of 25 000 clinically relevant SNPs in childhood acute lymphoblastic leukemia.
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• ChemProt: a disease chemical biology database.
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• Many putative endocrine disruptors inhibit prostaglandin synthesis.
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• Application of computational systems biology to explore environmental toxicity hazards.
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• Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.
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• Minocycline restores sAPPα levels and reduces the late histopathological consequences of traumatic brain injury in mice.
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• Minocycline restores olfactory bulb volume and olfactory behavior after traumatic brain injury in mice.
  Siopi E, Calabria S, Plotkine M, Marchand-Leroux C, Jafarian-Tehrani M : J Neurotrauma, 2011
• ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes.
  Magne L, Blanc E, Legrand B, Lucas D, Barouki R, Rouach H, Garlatti M : J Hepatol, 2011
• GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia.
  Charrière S, Peretti N, Bernard S, Di Filippo M, Sassolas A, Merlin M, Delay M, Debard C, Lefai E, Lachaux A, Moulin P, Marçais C : J Clin Endocrinol Metab, 2011
• Molecular screening of ADAMTSL2 gene in 33 patients reveals the genetic heterogeneity of geleophysic dysplasia.
  Allali S, Le Goff C, Pressac-Diebold I, Pfennig G, Mahaut C, Dagoneau N, Alanay Y, Brady AF, Crow YJ, Devriendt K, Drouin-Garraud V, Flori E, Geneviève D, Hennekam RC, Hurst J, Krakow D, Le Merrer M, Lichtenbelt KD, Lynch SA, Lyonnet S, MacDermot K, Mansour S, Megarbané A, Santos HG, Splitt M, Superti-Furga A, Unger S, Williams D, Munnich A, Cormier-Daire V : J Med Genet, 2011
• Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type.
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• Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson\\’s disease (Chylomicron retention disease).
  Georges A, Bonneau J, Bonnefont-Rousselot D, Champigneulle J, Rabès JP, Abifadel M, Aparicio T, Guenedet JC, Bruckert E, Boileau C, Morali A, Varret M, Aggerbeck LP, Samson-Bouma ME : Orphanet J Rare Dis, 2011
• Functional study of genes essential for autogamy and nuclear reorganization in Paramecium.
  Nowak JK, Gromadka R, Juszczuk M, Jerka-Dziadosz M, Maliszewska K, Mucchielli MH, Gout JF, Arnaiz O, Agier N, Tang T, Aggerbeck LP, Cohen J, Delacroix H, Sperling L, Herbert CJ, Zagulski M, Bétermier M : Eukaryot Cell, 2011
• Anderson\\’s disease/chylomicron retention disease in a Japanese patient with uniparental disomy 7 and a normal SAR1B gene protein coding sequence.
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• Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis.
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• Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.
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• Wnt/β-catenin signaling pathway is a direct enhancer of thyroid transcription factor-1 in human papillary thyroid carcinoma cells.
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• Understanding the neurospecificity of Prion protein signaling.
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• [miR-16 - a key for adaptive responses of neurons to fluoxetine].
  Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O : Med Sci (Paris), 2011
• New views on antidepressant action.
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• Differential effects of fibromodulin deficiency on mouse mandibular bones and teeth: a micro-CT time course study.
  Goldberg M, Marchadier A, Vidal C, Harichane Y, Kamoun-Goldrat A, Kellermann O, Kilts T, Young M : Cells Tissues Organs, 2011
• Neuritogenesis: the prion protein controls β1 integrin signaling activity.
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• MicroRNAs and depression.
  Mouillet-Richard S, Baudry A, Launay JM, Kellermann O : Neurobiol Dis, 2011
• Enamel alterations in serotonin 2B receptor knockout mice.
  Harichane Y, Dimitrova-Nakov S, Marchadier A, Collet C, Baudry A, Vidal C, Kamoun-Goldrat A, Kellermann O, Goldberg M : Eur J Oral Sci, 2011
• Management of pain induced by exercise and mobilization during physical therapy programs: views of patients and care providers.
  Alami S, Desjeux D, Lefèvre-Colau MM, Boisgard AS, Boccard E, Rannou F, Poiraudeau S : BMC Musculoskelet Disord, 2011
• Comparative study of MRI and power Doppler ultrasonography of the heel in patients with spondyloarthritis with and without heel pain and in controls.
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• Congenital lumbar spinal stenosis associated with Marfan syndrome.
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• Early effect of hyaluronic acid intra-articular injections on serum and urine biomarkers in patients with knee osteoarthritis: An open-label observational prospective study.
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• Understanding SOS (Son of Sevenless).
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• Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.
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• NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes.
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• GSH monoethyl ester rescues mitochondrial defects in cystic fibrosis models.
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• Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats.
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• Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization.
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• Apoptosis-Inducing Factor regulates skeletal muscle progenitor cell number and muscle phenotype.
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• HIV/SIV infection primes monocytes and dendritic cells for apoptosis.
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• hTERT promotes imatinib resistance in chronic myeloid leukemia cells: therapeutic implications.
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• Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss.
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• Comparison of the effects of erythropoietin and its carbamylated derivative on behaviour and hippocampal neurogenesis in mice.
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• VGLUT3 (vesicular glutamate transporter type 3) contribution to the regulation of serotonergic transmission and anxiety. (PDF)
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• OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres.
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• Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks.
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• Down-regulation of the phosphoenolpyruvate carboxykinase gene in human colon tumors and induction by omega-3 fatty acids.
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• Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.
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• Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin.
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• RAB23 mutation in a large family from Comoros Islands with Carpenter syndrome.
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• Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells.
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• Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor.
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• SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution.
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• Leptin induces nitric oxide-mediated inhibition of lipolysis and glyceroneogenesis in rat white adipose tissue.
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• In vivo NMDA receptor activation accelerates motor unit maturation, protects spinal motor neurons, and enhances SMN2 gene expression in severe spinal muscular atrophy mice.
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• Serotonergic 5-HT(2B) receptor controls tissue-nonspecific alkaline phosphatase activity in osteoblasts via eicosanoids and phosphatidylinositol-specific phospholipase C.
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• miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants.
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• Cell migration and metastasis markers as targets of environmental pollutants and the Aryl hydrocarbon receptor.
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• Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter.
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• 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2.
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• Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.
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• BRCA1 affects global DNA methylation through regulation of DNMT1.
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• Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation.
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• Self-reported sleep disturbances during cannabis withdrawal in cannabis-dependent outpatients with and without opioid dependence.
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• Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study.
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• Determination of 3,4-methylenedioxymethamphetamine and its five main metabolites in rat urine by solid-phase extraction and high performance liquid chromatography with on line mass spectrometry.
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• In vivo NMDA receptor activation accelerates motor unit maturation, protects spinal motor neurons, and enhances SMN2 gene expression in severe spinal muscular atrophy mice.
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• AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
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• Xenobiotic-metabolizing cytochromes p450 in human white adipose tissue: expression and induction
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• The serotonergic 5-HT2B receptor controls Tissue Non-specific Alkaline Phosphatase activity in osteoblasts via eicosanoïds and phosphoinositol-specific phospholipase C
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• The microRNA-16 targets the serotonergic ransporter: a new facet for adaptative responses to antidepressant
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• Hes1, a new target for interleukin 1beta in chondrocytes.
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• Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion.
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• Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal test.
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• Delayed hypoxic postconditioning protects against cerebral ischemia in the mouse.
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• Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor.
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• Minocycline effects on cerebral edema: relations with inflammatory and oxidative stress markers following traumatic brain injury in mice.
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• Abnormal oral-pharyngeal swallowing as cause of morbidity and early death in Stüve-Wiedemann syndrome.
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• DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short rib-polydactyly syndrome, type III.
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• Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrum.
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• The loss of the snoRNP chaperone Nopp140 from Cajal bodies of patient fibroblasts correlates with the severity of spinal muscular atrophy.
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• Characterisation of a human liver cystathionine beta synthase mRNA sequence corresponding to the c.[833T>C;844_845ins68] mutation in CBS gene.
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• The Xenopus MEF2 gene family: evidence of a role for XMEF2C in larval tendon development.
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• Motoneuron survival is promoted by specific exercise in a mouse model of amyotrophic lateral sclerosis.
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• 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.
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• Cellular prion protein coupling to TACE-dependent TNF-alpha shedding controls neurotransmitter catabolism in neuronal cells.
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• The cellular prion protein interacts with the tissue non-specific alkaline phosphatase in membrane microdomains of bioaminergic neuronal cells.
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• Production of reactive oxygen species is turned on and rapidly shut down in epithelial cells infected with Chlamydia trachomatis.
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• Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
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• Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity
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• Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue.
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• PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes.
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• Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme.
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• ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation.
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• Exercise-induced modulation of calcineurin activity parallels the time course of myofibre transitions.
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• Exercise-induced activation of NMDA receptor promotes motor unit development and survival in a type 2 spinal muscular atrophy model mouse.
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• Hypoxia down-regulates CCAAT/enhancer binding protein-alpha expression in breast cancer cells.
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• Prions impair bioaminergic functions through serotonin- or catecholamine-derived neurotoxins in neuronal cells.
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• CREB-dependent gene regulation by prion protein: impact on MMP-9 and beta-dystroglycan.
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• Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes.
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• IGF signaling pathway as a selective target of familial breast cancer therapy.
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