T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Dr. Benoît Schneider

CNRS researcher, DR-CNRS
Stem cells, Signaling and prions

benoit.schneider@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 22 09, room R294

Students :

Marjorie Alvarez
Chloé Bizingre

Benoit Schneider is currently co-head of the team “Stem Cells, Signaling and Prions” at the University Paris Descartes. He attended the Ecole Normale Supérieure (Cachan, 1993-1997), where he obtained a teaching degree in Biochemistry (“Agrégation”) and a Master 2 in Molecular and Cell biology (University Pierre-et-Marie Curie, Paris). After obtaining a Ph.D. in biochemistry, enzymology, and structural biology (University Pierre-et-Marie Curie, Paris) in 2001 at the Pasteur Institute (Paris), he joined the laboratory of Odile Kellermann (CNRS, Villejuif) as a post-doctoral fellow to work on neuronal differentiation and prions. He subsequently got a position as “Chargé de Recherche” (scientist) in 2003 in the National Center for Scientific Research of France (CNRS). He defended an “Habilitation à Diriger des Recherches” in 2007 and became Professor at the Ecole Polytechnique dispensing lectures in biochemistry and toxicology. In 2014, he was promoted to “Directeur de Recherche” (principal investigator) in the CNRS.

Recent Publications

Articles

• Serotonin in stem cell based-dental repair and bone formation: A review.
  Baudry A, Schneider B, Launay JM, Kellermann O : Biochimie, 2019
• Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response.
  Baudry A, Pietri M, Launay JM, Kellermann O, Schneider B : Front Neurosci, 2019
• Production of seedable Amyloid-β peptides in model of prion diseases upon PrP-induced PDK1 overactivation.
  Ezpeleta J, Baudouin V, Arellano-Anaya ZE, Boudet-Devaud F, Pietri M, Baudry A, Haeberlé AM, Bailly Y, Kellermann O, Launay JM, Schneider B : Nat Commun, 2019
• Alcohol exposure promotes DNA methyltransferase DNMT3A upregulation through reactive oxygen species-dependent mechanisms.
  Miozzo F, Arnould H, de Thonel A, Schang AL, Sabéran-Djoneidi D, Baudry A, Schneider B, Mezger V : Cell Stress Chaperones, 2018
• Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase.
  Ezpeleta J, Boudet-Devaud F, Pietri M, Baudry A, Baudouin V, Alleaume-Butaux A, Dagoneau N, Kellermann O, Launay JM, Schneider B : Sci Rep, 2017
• Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue.
  Mehrabian M, Brethour D, Williams D, Wang H, Arnould H, Schneider B, Schmitt-Ulms G : PLoS One, 2016
• Essential Roles of Dopamine and Serotonin in Tooth Repair: Functional Interplay Between Odontogenic Stem Cells and Platelets.
  Baudry A, Alleaume-Butaux A, Dimitrova-Nakov S, Goldberg M, Schneider B, Launay JM, Kellermann O : Stem Cells, 2015
• [Activated platelets help to repair teeth through recruitment of pulpal stem cells].
  Baudry A, Launay JM, Goldberg M, Schneider B, Kellermann O : Med Sci (Paris), 2015
• Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation.
  Alleaume-Butaux A, Nicot S, Pietri M, Baudry A, Dakowski C, Tixador P, Ardila-Osorio H, Haeberlé AM, Bailly Y, Peyrin JM, Launay JM, Kellermann O, Schneider B : PLoS Pathog, 2015
• A PrP(C)-caveolin-Lyn complex negatively controls neuronal GSK3β and serotonin 1B receptor.
  Hernandez-Rapp J, Martin-Lannerée S, Hirsch TZ, Pradines E, Alleaume-Butaux A, Schneider B, Baudry A, Launay JM, Mouillet-Richard S : Sci Rep, 2014
• [From prion diseases to Alzheimer\\’s disease: a common therapeutic target, PDK1].
  Pietri M, Alleaume-Butaux A, Launay JM, Kellermann O, Schneider B : Med Sci (Paris), 2014
• Synapto-protective drugs evaluation in reconstructed neuronal network.
  Deleglise B, Lassus B, Soubeyre V, Alleaume-Butaux A, Hjorth JJ, Vignes M, Schneider B, Brugg B, Viovy JL, Peyrin JM : PLoS One, 2013
• PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer\\’s diseases.
  Pietri M, Dakowski C, Hannaoui S, Alleaume-Butaux A, Hernandez-Rapp J, Ragagnin A, Mouillet-Richard S, Haik S, Bailly Y, Peyrin JM, Launay JM, Kellermann O, Schneider B : Nat Med, 2013
• Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected mice.
  Sacquin A, Chaigneau T, Defaweux V, Adam M, Schneider B, Bruley Rosset M, Eloit M : Brain Behav Immun, 2012
• Understanding the neurospecificity of Prion protein signaling.
  Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S : Front Biosci (Landmark Ed), 2011
• [miR-16 - a key for adaptive responses of neurons to fluoxetine].
  Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O : Med Sci (Paris), 2011
• Neuritogenesis: the prion protein controls β1 integrin signaling activity.
  Loubet D, Dakowski C, Pietri M, Pradines E, Bernard S, Callebert J, Ardila-Osorio H, Mouillet-Richard S, Launay JM, Kellermann O, Schneider B : FASEB J, 2011
• miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants.
  Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O : Science, 2010
• The microRNA-16 targets the serotonergic ransporter: a new facet for adaptative responses to antidepressant
  Baudry A, Mouillet-Richard S, Schneider B, J-M Launay, O Kellermann : Science, 2010
• Cellular prion protein coupling to TACE-dependent TNF-alpha shedding controls neurotransmitter catabolism in neuronal cells.
  Pradines E, Loubet D, Mouillet-Richard S, Manivet P, Launay JM, Kellermann O, Schneider B : J Neurochem, 2009
• The cellular prion protein interacts with the tissue non-specific alkaline phosphatase in membrane microdomains of bioaminergic neuronal cells.
  Ermonval M, Baudry A, Baychelier F, Pradines E, Pietri M, Oda K, Schneider B, Mouillet-Richard S, Launay JM, Kellermann O : PLoS One, 2009
• Production of reactive oxygen species is turned on and rapidly shut down in epithelial cells infected with Chlamydia trachomatis.
  Boncompain G, Schneider B, Delevoye C, Kellermann O, Dautry-Varsat A, Subtil A : Infect Immun, 2009
• Prions impair bioaminergic functions through serotonin- or catecholamine-derived neurotoxins in neuronal cells.
  Mouillet-Richard S, Nishida N, Pradines E, Laude H, Schneider B, Féraudet C, Grassi J, Launay JM, Lehmann S, Kellermann O : J Biol Chem, 2008
• CREB-dependent gene regulation by prion protein: impact on MMP-9 and beta-dystroglycan.
  Pradines E, Loubet D, Schneider B, Launay JM, Kellermann O, Mouillet-Richard S : Cell Signal, 2008
• Cellular prion protein signaling in serotonergic neuronal cells.
  Mouillet-Richard S, Schneider B, Pradines E, Pietri M, Ermonval M, Grassi J, Richards JG, Mutel V, Launay JM, Kellermann O : Ann N Y Acad Sci, 2007
• Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells.
  Pietri M, Caprini A, Mouillet-Richard S, Pradines E, Ermonval M, Grassi J, Kellermann O, Schneider B : J Biol Chem, 2006
• Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells.
  Launay JM, Schneider B, Loric S, Da Prada M, Kellermann O : FASEB J, 2006
• Control of bioamine metabolism by 5-HT2B and alpha 1D autoreceptors through reactive oxygen species and tumor necrosis factor-alpha signaling in neuronal cells.
  Schneider B, Pietri M, Mouillet-Richard S, Ermonval M, Mutel V, Launay JM, Kellermann O : Ann N Y Acad Sci, 2006
• Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells.
  Pietri M, Schneider B, Mouillet-Richard S, Ermonval M, Mutel V, Launay JM, Kellermann O : FASEB J, 2005