T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06
Fax : +33 (0) 1 42 86 38 68
Olivier Biondi
Lecturer
Degeneration and plasticity of the locomotor system
olivier.biondi@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 21 53, room H330
Olivier Biondi obtained a BSc in Sport and Exercise Science at the University of Evry (France, 2000-2004) followed by a Master in cellular biology at the Paris Descartes university (2004-2005). In 2008, he earned a doctorate in cellular neurobiology in 2008 from the Paris Descartes University at the Center for the Study of Sensorimotricity (UMR 8194 of the CNRS). His work focused on the effects of physical exercise in mouse models of infantile spinal muscular atrophy, a degenerative motor neuron disease. He then completed a postdoctoral research in the Neuromuscular System and Inflation team (INSERM U955) at the Department of Anatomy and Pathology at Mondor Hospital in Créteil (France) on muscular adaptations in a limb girdle muscular dystrophy, dysfernilopathies (2008-2011). He was then appointed associate-professor in cell biology at the Paris Descartes university in 2011. He is active in research and teaching at the Faculty of Fundamental and Biomedical Sciences in the university Saints-Pères center.
His line of research focuses on describing the pathophysiological mechanisms of neurodegenerative diseases specifically affecting motor neuron (Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis) using physical exercise as a tool for soliciting motor units. He was able to show that not only physical exercise could be beneficial in these two pathologies but also that these benefits passed through cell-specific neuroprotection and dependent on the type of activity. Thus, when practicing physical exercises with different intensities, only the subpopulation of activated-neurons (fast motor unit after high intensity exercise vs slow motor unit after low intensity exercise) is protected. This work allowed the setting up of a national clinical trial in spinal muscular atrophy (PHRC ExerASI, N° ID RCB 2013-A01331-44), of which Olivier Biondi is the scientific officer. This study aims to assess the impact of active physiotherapy in this disease and to develop novel noninvasive tools for the analysis of the motor function of patients with neurodegenerative diseases.
Recent Publications
Articles
- Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway.
D’Amico D, Biondi O, Januel C, Bezier C, Sapaly D, Clerc Z, El Khoury M, Sundaram VK, Houdebine L, Josse T, Della Gaspera B, Martinat C, Massaad C, Weill L, Charbonnier F : Neuropathol Appl Neurobiol, 2022 - Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy.
Sapaly D, Dos Santos M, Delers P, Biondi O, Quérol G, Houdebine L, Khoobarry K, Girardet F, Burlet P, Armand AS, Chanoine C, Bureau JF, Charbonnier F, Lefebvre S : Sci Rep, 2018 - Long-term exercise-specific neuroprotection in Spinal Muscular Atrophy-like mice.
Chali F, Desseille C, Houdebine L, Benoit E, Rouquet T, Bariohay B, Lopes P, Branchu J, Gaspera BD, Pariset C, Chanoine C, Charbonnier F, Biondi O : J Physiol, 2016 - IGF-1R Reduction Triggers Neuroprotective Signaling Pathways in Spinal Muscular Atrophy Mice.
Biondi O, Branchu J, Ben Salah A, Houdebine L, Bertin L, Chali F, Desseille C, Weill L, Sanchez G, Lancelin C, Aïd S, Lopes P, Pariset C, Lécolle S, Côté J, Holzenberger M, Chanoine C, Massaad C, Charbonnier F : J Neurosci, 2015 - Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells.
Branchu J, Biondi O, Chali F, Collin T, Leroy F, Mamchaoui K, Makoukji J, Pariset C, Lopes P, Massaad C, Chanoine C, Charbonnier F : J Neurosci, 2013 - A novel function for the survival motoneuron protein as a translational regulator.
Sanchez G, Dury AY, Murray LM, Biondi O, Tadesse H, El Fatimy R, Kothary R, Charbonnier F, Khandjian EW, Côté J : Hum Mol Genet, 2012 - Physical exercise reduces cardiac defects in type 2 spinal muscular atrophy-like mice.
Biondi O, Lopes P, Desseille C, Branchu J, Chali F, Salah AB, Pariset C, Chanoine C, Charbonnier F : J Physiol, 2012 - Apoptosis-Inducing Factor regulates skeletal muscle progenitor cell number and muscle phenotype.
Armand AS, Laziz I, Djeghloul D, Lécolle S, Bertrand AT, Biondi O, De Windt LJ, Chanoine C : PLoS One, 2011 - In vivo NMDA receptor activation accelerates motor unit maturation, protects spinal motor neurons, and enhances SMN2 gene expression in severe spinal muscular atrophy mice.
Biondi O, Branchu J, Sanchez G, Lancelin C, Deforges S, Lopes P, Pariset C, Lécolle S, Côté J, Chanoine C, Charbonnier F : J Neurosci, 2010 - In vivo NMDA receptor activation accelerates motor unit maturation, protects spinal motor neurons, and enhances SMN2 gene expression in severe spinal muscular atrophy mice.
Biondi O, Branchu J, Sanchez G, Lancelin C, Deforges S, Lopes P, Pariset C, Lécolle S, Côté J, Chanoine C, Charbonnier F : J Neurosci, 2010 - Motoneuron survival is promoted by specific exercise in a mouse model of amyotrophic lateral sclerosis.
Deforges S, Branchu J, Biondi O, Grondard C, Pariset C, Lécolle S, Lopes P, Vidal PP, Chanoine C, Charbonnier F : J Physiol, 2009 - Exercise-induced modulation of calcineurin activity parallels the time course of myofibre transitions.
Grondard C, Biondi O, Pariset C, Lopes P, Deforges S, Lécolle S, Gaspera BD, Gallien CL, Chanoine C, Charbonnier F : J Cell Physiol, 2008 - Exercise-induced activation of NMDA receptor promotes motor unit development and survival in a type 2 spinal muscular atrophy model mouse.
Biondi O, Grondard C, Lécolle S, Deforges S, Pariset C, Lopes P, Cifuentes-Diaz C, Li H, della Gaspera B, Chanoine C, Charbonnier F : J Neurosci, 2008 - Regular exercise prolongs survival in a type 2 spinal muscular atrophy model mouse.
Grondard C, Biondi O, Armand AS, Lécolle S, Della Gaspera B, Pariset C, Li H, Gallien CL, Vidal PP, Chanoine C, Charbonnier F : J Neurosci, 2005