T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Delphine Sapaly

Engineer
Degeneration and plasticity of the locomotor system

delphine.sapaly@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 21 53, room H330

Delphine Sapaly, engineer in cellular biology, has worked since 2014 in Frédéric Charbonnier’s team in charge of imaging approaches and as lab manager.

Graduated from the ISARA-Lyon engineering school, she specialized in medical biology during her professional career at Inserm. She joined Frédéric Charbonnier’s team in 2014. She first worked with Suzie Lefebvre on a valorization project funded by the company Satt IDF Innov, which investigated the effects of a candidate drug for the therapy of Spinal Muscular Atrophy (SMA). The goal of the project was to understand the molecular mechanisms of Flunarizine that have therapeutic potential in a mouse model of SMA. (Sapaly et al Sci Rep, 2018)

In 2016, she was recruited as engineer at Paris Descartes University, in the same team. She is in charge of imaging approaches of the team and she is carrying the role of lab manager.

In parallel, she is studying the perturbation of the energetic metabolism in several human severe neuromuscular diseases, including SMA and Amyotrophic Lateral Sclerosis.

Recent Publications

Articles

• Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway.
  D’Amico D, Biondi O, Januel C, Bezier C, Sapaly D, Clerc Z, El Khoury M, Sundaram VK, Houdebine L, Josse T, Della Gaspera B, Martinat C, Massaad C, Weill L, Charbonnier F : Neuropathol Appl Neurobiol, 2022
• The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases.
  Sapaly D, Delers P, Coridon J, Salman B, Letourneur F, Dumont F, Lefebvre S : Front Mol Biosci, 2020
• Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy.
  Sapaly D, Dos Santos M, Delers P, Biondi O, Quérol G, Houdebine L, Khoobarry K, Girardet F, Burlet P, Armand AS, Chanoine C, Bureau JF, Charbonnier F, Lefebvre S : Sci Rep, 2018