T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Sophie Bernard

University Professor
Myelination and Nervous system pathologies

sophie.bernard@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 20 46, room H344 A

Sophie Bernard is Professor of Physics at the Faculty of Basic and Biomedical Sciences of Université de Paris. Her current research is focused on the real-time analysis of the process of myelination, the quantification of cytoskeleton remodeling and Wnt signaling. She is the Chair of the international Master’s program in BioMedical Engineering BME Paris and co-head of the Institute of Neuroscience and Cognition

Research interests

• Implication of the Wnt and LXR signaling pathways during myelination
• Wnt/b-catenin signaling and cytoskeletal remodeling of glial cells
• Multivariate statistical analysis of biological data & high-dimensional data analysis

Methods

Synchrotron radiation Fourier Transform Infrared microspectroscopy

Atomic force microscopy

X-ray diffraction

Surface Enhanced Raman spectroscopy

Biomimetic membranes

Teaching

General physics for undergraduate students: Classical Mechanics, Electricity, Wave phenomena, Optics, Electromagnetism, Fluid Mechanics, Advanced Spectroscopy.

Biophysics for postgraduate students: Physics of Bioimaging, Medicine and Science.

Links

• Master of BioMedical Engineering: http://www.bme-paris.com
• Institute of Neuroscience and Cognition: http://inc.parisdescartes.fr
• Linkedin: https://www.linkedin.com/in/sophie-bernard-80675985

Recent Publications

Articles

• Wnt and lithium: a common destiny in the therapy of nervous system pathologies?
  Meffre D, Grenier J, Bernard S, Courtin F, Dudev T, Shackleford G, Jafarian-Tehrani M, Massaad C : Cell Mol Life Sci, 2013
• Lithium enhances remyelination of peripheral nerves.
  Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C : Proc Natl Acad Sci U S A, 2012
• GPIHBP1 C89F neomutation and hydrophobic C-terminal domain G175R mutation in two pedigrees with severe hyperchylomicronemia.
  Charrière S, Peretti N, Bernard S, Di Filippo M, Sassolas A, Merlin M, Delay M, Debard C, Lefai E, Lachaux A, Moulin P, Marçais C : J Clin Endocrinol Metab, 2011
• Neuritogenesis: the prion protein controls β1 integrin signaling activity.
  Loubet D, Dakowski C, Pietri M, Pradines E, Bernard S, Callebert J, Ardila-Osorio H, Mouillet-Richard S, Launay JM, Kellermann O, Schneider B : FASEB J, 2011
• Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.
  Pommier AJ, Alves G, Viennois E, Bernard S, Communal Y, Sion B, Marceau G, Damon C, Mouzat K, Caira F, Baron S, Lobaccaro JM : Oncogene, 2010
• Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin.
  Gonzalvez F, Pariselli F, Jalmar O, Dupaigne P, Sureau F, Dellinger M, Hendrickson EA, Bernard S, Petit PX : PLoS One, 2010
• Interaction of the alpha-helical H6 peptide from the pro-apoptotic protein tBid with cardiolipin.
  Petit PX, Dupaigne P, Pariselli F, Gonzalvez F, Etienne F, Rameau C, Bernard S : FEBS J, 2009
• 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.
  Trousson A, Bernard S, Petit PX, Liere P, Pianos A, El Hadri K, Lobaccaro JM, Ghandour MS, Raymondjean M, Schumacher M, Massaad C : J Neurochem, 2009
• Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte death.
  Trousson A, Makoukji J, Petit PX, Bernard S, Slomianny C, Schumacher M, Massaad C : PLoS One, 2009
• Cardiolipin packing ability studied by grazing incidence X-ray diffraction.
  Etienne F, Roche Y, Peretti P, Bernard S : Chem Phys Lipids, 2007
• Influence of the chain length of ubiquinones on their interaction with DPPC in mixed monolayers.
  Roche Y, Peretti P, Bernard S : Biochim Biophys Acta, 2006
• Interfacial assembly of a phospholipid Langmuir monolayer by electrodeposited silver colloids.
  Mangeney C, Dupres V, Bernard S : J Colloid Interface Sci, 2006
• Latex and hollow particles of reactive polypyrrole: preparation, properties, and decoration by gold nanospheres.
  Mangeney C, Bousalem S, Connan C, Vaulay MJ, Bernard S, Chehimi MM : Langmuir, 2006