T3S-1124 - UMR-S 1124
Université de Paris
Campus Saint-Germain-des-Près
45 rue des Saints Pères
75270 Paris Cedex 06
Fax : +33 (0) 1 42 86 38 68
Dr. Christelle Nguyen
Associate professor, MCU-PH Paris Descartes
Degeneration and plasticity of the locomotor system
christelle.nguyen2@-Code to remove to avoid SPAM-aphp.fr
+ 33 1 42 86 38 71, room P453B
Dr Christelle Nguyen, MD, PhD, is a clinician scientist and Associate Professor of Physical and Rehabilitation Medicine (PRM) at the Faculté de Médecine Paris Descartes, Université de Paris.
She obtained her MD in 2010 at the Faculté de Médecine Paris Pierre and Marie Curie and holds a PhD in cellular biology obtained in 2015 at the Université Paris Diderot. After a 2-year Visiting Academic position at the Institute For Molecular Bioscience at the University of Queensland in Australia (Associate Professor Mathias François lab), she joined Professor François Rannou lab in 2014, then Professor Frédéric Charbonnier lab in 2019 (INSERM UMR 1124, Faculté des Sciences Fondamentales et Biomédicales, Université de Paris). She is also consultant in the department of PRM at Cochin hospital since 2014.
She is currently leading translational research projects aiming at: 1/ better understanding molecular mechanisms involved in intervertebral disc and articular cartilage diseases, using original in vitro and in vivo models, 2/ assessing the efficacy and safety of targeted non-pharmacological interventions in musculoskeletal disorders including osteoarthritis, intervertebral disc diseases and systemic sclerosis, and 3/ developing instruments to measure disability specific to these conditions.
Dr Christelle Nguyen is author of more than 60 articles in peer-reviewed journals. Her research projects have raised 1,900 k€ fundings to date. She has been awarded the Young Investigator Prize from the Bettencourt Schueller Foundation in 2012. She is member of the French Societies of PRM (SOFMER) and of Rheumatology (SFR), of the Scleroderma Patient-centered Intervention Network (SPIN) and of the experts group on physical activity at the French National Institute of Health and Medical Research (INSERM). She is Editorial Board member for the medical journal PLOS Medicine.
Main publications
- Low back pain
Nguyen C, Lefèvre-Colau MM, Kennedy DJ, Schneider BJ, Rannou F. Lancet. 2018 Dec 15;392(10164):2547. - Intradiscal Glucocorticoid Injection for Patients With Chronic Low Back Pain Associated With Active Discopathy: A Randomized Trial
Nguyen C, Boutron I, Baron G, Sanchez K, Palazzo C, Benchimol R, Paris G, James-Belin É, Lefèvre-Colau MM, Beaudreuil J, Laredo JD, Béra-Louville A, Cotten A, Drapé JL, Feydy A, Ravaud P, Rannou F, Poiraudeau S. Ann Intern Med. 2017 Apr 18;166(8):547-556. - From Modic 1 vertebral-endplate subchondral bone signal changes detected by MRI to the concept of ‘active discopathy’.
Nguyen C, Poiraudeau S, Rannou F. Ann Rheum Dis. 2015 Aug;74(8):1488-94. - Revisiting spatial distribution and biochemical composition of calcium-containing crystals in human osteoarthritic articular cartilage.
Nguyen C, Bazin D, Daudon M, Chatron-Colliet A, Hannouche D, Bianchi A, Côme D, So A, Busso N, Busso N, Lioté F, Ea HK : Arthritis Res Ther. 2013;15(5):R103 - Intracellular calcium oscillations in articular chondrocytes induced by basic calcium phosphate crystals lead to cartilage degradation.
Nguyen C, Lieberherr M, Bordat C, Velard F, Côme D, Lioté F, Ea HK : Osteoarthritis Cartilage. 2012 Nov;20(11):1399-408
Recent Publications
Articles
- Aging Cartilage in Wild-Type Mice: An Observational Study.
Akoum J, Tahiri K, Corvol MT, Borderie D, Étienne F, Rannou F, Nguyen C : Cartilage, 2020 - Intradiscal Glucocorticoid Injection for Patients With Chronic Low Back Pain Associated With Active Discopathy: A Randomized Trial.
Nguyen C, Boutron I, Baron G, Sanchez K, Palazzo C, Benchimol R, Paris G, James-Belin É, Lefèvre-Colau MM, Beaudreuil J, Laredo JD, Béra-Louville A, Cotten A, Drapé JL, Feydy A, Ravaud P, Rannou F, Poiraudeau S : Ann Intern Med, 2017 - Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review.
Nguyen C, Savouret JF, Widerak M, Corvol MT, Rannou F : Nutrients, 2017 - High-intensity versus low-intensity physical activity or exercise in people with hip or knee osteoarthritis.
Regnaux JP, Lefevre-Colau MM, Trinquart L, Nguyen C, Boutron I, Brosseau L, Ravaud P : Cochrane Database Syst Rev, 2015 - From Modic 1 vertebral-endplate subchondral bone signal changes detected by MRI to the concept of \\’active discopathy\\’.
Nguyen C, Poiraudeau S, Rannou F : Ann Rheum Dis, 2015 - [Neuromuscular dynamic scapular winging: Clinical, electromyographic and magnetic resonance imaging diagnosis].
Nguyen C, Guérini H, Roren A, Zauderer J, Vuillemin V, Seror P, Ouaknine M, Palazzo C, Bourdet C, Pluot É, Roby-Brami A, Drapé JL, Rannou F, Poiraudeau S, Lefèvre-Colau MM : Presse Med, 2015 - Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross-sectional survey.
Nguyen C, Ranque B, Baubet T, Bérezné A, Mestre-Stanislas C, Rannou F, Papelard A, Morell-Dubois S, Revel M, Moro MR, Guillevin L, Poiraudeau S, Mouthon L : PLoS One, 2014 - Pathogenic role of basic calcium phosphate crystals in destructive arthropathies.
Ea HK, Chobaz V, Nguyen C, Nasi S, van Lent P, Daudon M, Dessombz A, Bazin D, McCarthy G, Jolles-Haeberli B, Ives A, Van Linthoudt D, So A, Lioté F, Busso N : PLoS One, 2013 - Revisiting spatial distribution and biochemical composition of calcium-containing crystals in human osteoarthritic articular cartilage.
Nguyen C, Bazin D, Daudon M, Chatron-Colliet A, Hannouche D, Bianchi A, Côme D, So A, Busso N, Busso N, Lioté F, Ea HK : Arthritis Res Ther, 2013 - Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo.
Bowles J, Secker G, Nguyen C, Kazenwadel J, Truong V, Frampton E, Curtis C, Skoczylas R, Davidson TL, Miura N, Hong YK, Koopman P, Harvey NL, François M : Dev Biol, 2013 - The status of strontium in biological apatites: an XANES/EXAFS investigation.
Bazin D, Dessombz A, Nguyen C, Ea HK, Lioté F, Rehr J, Chappard C, Rouzière S, Thiaudière D, Reguer S, Daudon M : J Synchrotron Radiat, 2013 - Comparative study of MRI and power Doppler ultrasonography of the heel in patients with spondyloarthritis with and without heel pain and in controls.
Feydy A, Lavie-Brion MC, Gossec L, Lavie F, Guerini H, Nguyen C, Rannou F, Drapé JL, Dougados M : Ann Rheum Dis, 2011 - Congenital lumbar spinal stenosis associated with Marfan syndrome.
Nguyen C, Papelard A, Schnitzler A, Mangione P, Poiraudeau S, Rannou F : Joint Bone Spine, 2011