Despite the severe impact of the diseases of demyelination on patients’ lives and society, little is known about the processes of de/re/myelination. Our aim is to build a research group working on myelin physiology and pathologies affecting the nervous system. The main focuses are: (i) to identify new signaling pathways involved in myelination and demyelination; (ii) to examine their impact on nervous system pathologies (Multiple Sclerosis [MS], Nerve Injuries, Diabetic Peripheral Neuropathies [DPN], Traumatic Brain Injuries [TBI]); (iii) to study the impact of the environmental factors (stress, pollutants) on normal myelination process and on enhancing insults to cause exacerbated demyelination and co-morbidity.
We will develop an interdisciplinary research based on preclinical and clinical approaches using molecular and cell biology, behavior, biophysics and physiology to study the myelination process as well as de/remyelination following pathological conditions. We will focus our work on oxysterol/LXR, dioxin/AhR and ADAM10 pathways as well as oxidative stress. Our project will allow deciphering the signaling pathways involved in myelination process and their dysregulation during demyelination. It will also open new avenues for the treatment of myelin pathologies.
Team leader
Charbel Massaad, university Professor, Myelination and Nervous system pathologiescharbel.massaad@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 22 22, room P410
Members
Céline Becker, Assistant Engineer, Myelination and Nervous system pathologiesceline.becker@-Code to remove to avoid SPAM-inserm.fr, room H330
Christel Becker, Associate professor, MCU Paris Descartes, Myelination and Nervous system pathologieschristel.becker@-Code to remove to avoid SPAM-u-paris.fr
Jean-Jacques Benoliel, Associate professor, MCU-PH Paris Descartes, Myelination and Nervous system pathologiesjean-jacques.benoliel@-Code to remove to avoid SPAM-upmc.fr, room H344
Sophie Bernard, University Professor, Myelination and Nervous system pathologiessophie.bernard@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 20 46, room H344 A
Franck Brouillard, Associate professor, MCU Paris Descartes, Myelination and Nervous system pathologiesfranck.brouillard@-Code to remove to avoid SPAM-inserm.fr, room H344
Tatiana El Jakh, PhD student, Myelination and Nervous system pathologiestatiana.el_jalkh@-Code to remove to avoid SPAM-etu.parisdescartes.fr, room H330
Mohamed El Masri, PhD student, Myelination and Nervous system pathologiesmohamed.el_massry@-Code to remove to avoid SPAM-etu.parisdescartes.fr, room H330
Julia Fath, PhD Student, Myelination and Nervous system pathologiesjulia.fath@-Code to remove to avoid SPAM-u-paris.fr
Julien Grenier, Associate professor, MCU Paris Descartes, Myelination and Nervous system pathologiesjulien.grenier@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 38 87, room H330
Mehrnaz Jafarian-Tehrani, University Professor, Myelination and Nervous system pathologiesmehrnaz.jafarian-tehrani@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 99 76, room H330
Damien Le Menuet, INSERM researcher, CR- INSERM, Myelination and Nervous system pathologiesdamien.le-menuet@-Code to remove to avoid SPAM-inserm.fr, +33 1 70 64 99 76, room H330
Delphine Meffre, Associate professor, MCU Paris Descartes, Myelination and Nervous system pathologiesdelphine.meffre@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 22 73, room H344
Aïda Padilla Ferrer, PhD student, Myelination and Nervous system pathologiesaida.padilla-ferrer@-Code to remove to avoid SPAM-u-paris.fr, room H330
Hugo Salmon, Assistant Professor, Myelination and Nervous system pathologieshugo.salmon@-Code to remove to avoid SPAM-u-paris.fr
Anne Simon, Engineer, Myelination and Nervous system pathologiesanne.simon@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 21 53 or 38 87, room H330
Venkat krishnan Sundaram, PhD Student, Myelination and Nervous system pathologiesvenkatkrishnan.sundaram@-Code to remove to avoid SPAM-u-paris.fr, room H330
Recent Publications
Article
- Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway.
D’Amico D, Biondi O, Januel C, Bezier C, Sapaly D, Clerc Z, El Khoury M, Sundaram VK, Houdebine L, Josse T, Della Gaspera B, Martinat C, Massaad C, Weill L, Charbonnier F : Neuropathol Appl Neurobiol, 2022
